| Predicted Trait | |
| Reported Trait | Volume of grey matter in Parahippocampal Gyrus, anterior division (L) |
| Mapped Trait(s) | |
| Additional Trait Information | https://biobankengine.stanford.edu/RIVAS_HG19/snpnet/INI25848 |
| Score Construction | |
| PGS Name | GBE_INI25848 |
| Development Method | |
| Name | snpnet |
| Parameters | NR |
| Variants | |
| Original Genome Build | GRCh37 |
| Number of Variants | 1,724 |
| Effect Weight Type | NR |
| PGS Source | |
| PGS Catalog Publication (PGP) ID | PGP000244 |
| Citation (link to publication) | Tanigawa Y et al. PLoS Genet (2022) |
| Ancestry Distribution | |
| Score Development/Training | European: 100% 22,320 individuals (100%) |
| PGS Evaluation | European: 40% African: 20% East Asian: 20% South Asian: 20% 5 Sample Sets |
| Study Identifiers | Sample Numbers | Sample Ancestry | Cohort(s) | Phenotype Definitions & Methods | Age of Study Participants | Participant Follow-up Time | Additional Ancestry Description | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| — | 22,320 individuals | European | UKB | — | — | — | white British ancestry | Training + validation cohort (train_val) |
|
PGS Performance Metric ID (PPM) |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|
| PPM006750 | PSS006591| African Ancestry| 200 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Vol. of grey matter in Parahippocampal Gyrus, anterior division (L) | — | — | R²: 0.27955 [0.26104, 0.29807] Incremental R2 (full-covars): -0.02498 PGS R2 (no covariates): 0.00805 [0.00373, 0.01238] |
age, sex, UKB array type, Genotype PCs | — |
| PPM006751 | PSS006592| East Asian Ancestry| 113 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Vol. of grey matter in Parahippocampal Gyrus, anterior division (L) | — | — | R²: 0.20592 [0.17177, 0.24006] Incremental R2 (full-covars): -0.03645 PGS R2 (no covariates): 0.00822 [-0.0003, 0.01674] |
age, sex, UKB array type, Genotype PCs | — |
| PPM006752 | PSS006593| European Ancestry| 1,739 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Vol. of grey matter in Parahippocampal Gyrus, anterior division (L) | — | — | R²: 0.21082 [0.20182, 0.21981] Incremental R2 (full-covars): -0.00108 PGS R2 (no covariates): 0.00219 [0.00103, 0.00335] |
age, sex, UKB array type, Genotype PCs | — |
| PPM006753 | PSS006594| South Asian Ancestry| 329 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Vol. of grey matter in Parahippocampal Gyrus, anterior division (L) | — | — | R²: 0.23973 [0.22325, 0.25622] Incremental R2 (full-covars): 0.01199 PGS R2 (no covariates): 0.00677 [0.00315, 0.01039] |
age, sex, UKB array type, Genotype PCs | — |
| PPM006754 | PSS006595| European Ancestry| 5,443 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Vol. of grey matter in Parahippocampal Gyrus, anterior division (L) | — | — | R²: 0.2031 [0.19767, 0.20852] Incremental R2 (full-covars): 0.00654 PGS R2 (no covariates): 0.01039 [0.00887, 0.01192] |
age, sex, UKB array type, Genotype PCs | — |
|
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| PSS006591 | — | — | 200 individuals | — | African unspecified | — | UKB | — |
| PSS006592 | — | — | 113 individuals | — | East Asian | — | UKB | — |
| PSS006593 | — | — | 1,739 individuals | — | European | non-white British ancestry | UKB | — |
| PSS006594 | — | — | 329 individuals | — | South Asian | — | UKB | — |
| PSS006595 | — | — | 5,443 individuals | — | European | white British ancestry | UKB | Testing cohort (heldout set) |