| Predicted Trait | |
| Reported Trait | Volume of grey matter in Parahippocampal Gyrus, posterior division (L) |
| Mapped Trait(s) | |
| Additional Trait Information | https://biobankengine.stanford.edu/RIVAS_HG19/snpnet/INI25850 |
| Score Construction | |
| PGS Name | GBE_INI25850 |
| Development Method | |
| Name | snpnet |
| Parameters | NR |
| Variants | |
| Original Genome Build | GRCh37 |
| Number of Variants | 1,120 |
| Effect Weight Type | NR |
| PGS Source | |
| PGS Catalog Publication (PGP) ID | PGP000244 |
| Citation (link to publication) | Tanigawa Y et al. PLoS Genet (2022) |
| Ancestry Distribution | |
| Score Development/Training | European: 100% 22,320 individuals (100%) |
| PGS Evaluation | European: 40% African: 20% East Asian: 20% South Asian: 20% 5 Sample Sets |
| Study Identifiers | Sample Numbers | Sample Ancestry | Cohort(s) | Phenotype Definitions & Methods | Age of Study Participants | Participant Follow-up Time | Additional Ancestry Description | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| — | 22,320 individuals | European | UKB | — | — | — | white British ancestry | Training + validation cohort (train_val) |
|
PGS Performance Metric ID (PPM) |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|
| PPM006760 | PSS006601| African Ancestry| 200 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Vol. of grey matter in Parahippocampal Gyrus, posterior division (L) | — | — | R²: 0.08469 [0.07174, 0.09763] Incremental R2 (full-covars): -0.0246 PGS R2 (no covariates): 0.00528 [0.00177, 0.0088] |
age, sex, UKB array type, Genotype PCs | — |
| PPM006761 | PSS006602| East Asian Ancestry| 113 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Vol. of grey matter in Parahippocampal Gyrus, posterior division (L) | — | — | R²: 0.14255 [0.11187, 0.17323] Incremental R2 (full-covars): -0.00794 PGS R2 (no covariates): 0.00011 [-0.00088, 0.00109] |
age, sex, UKB array type, Genotype PCs | — |
| PPM006762 | PSS006603| European Ancestry| 1,739 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Vol. of grey matter in Parahippocampal Gyrus, posterior division (L) | — | — | R²: 0.15465 [0.14639, 0.16291] Incremental R2 (full-covars): 0.01501 PGS R2 (no covariates): 0.01563 [0.01257, 0.01868] |
age, sex, UKB array type, Genotype PCs | — |
| PPM006763 | PSS006604| South Asian Ancestry| 329 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Vol. of grey matter in Parahippocampal Gyrus, posterior division (L) | — | — | R²: 0.21929 [0.20311, 0.23548] Incremental R2 (full-covars): -0.00242 PGS R2 (no covariates): 0.00632 [0.00283, 0.00982] |
age, sex, UKB array type, Genotype PCs | — |
| PPM006764 | PSS006605| European Ancestry| 5,443 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Vol. of grey matter in Parahippocampal Gyrus, posterior division (L) | — | — | R²: 0.13089 [0.12614, 0.13563] Incremental R2 (full-covars): 0.01316 PGS R2 (no covariates): 0.01418 [0.01241, 0.01596] |
age, sex, UKB array type, Genotype PCs | — |
|
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| PSS006601 | — | — | 200 individuals | — | African unspecified | — | UKB | — |
| PSS006602 | — | — | 113 individuals | — | East Asian | — | UKB | — |
| PSS006603 | — | — | 1,739 individuals | — | European | non-white British ancestry | UKB | — |
| PSS006604 | — | — | 329 individuals | — | South Asian | — | UKB | — |
| PSS006605 | — | — | 5,443 individuals | — | European | white British ancestry | UKB | Testing cohort (heldout set) |