| Predicted Trait | |
| Reported Trait | Volume of grey matter in Parahippocampal Gyrus, posterior division (R) |
| Mapped Trait(s) | |
| Additional Trait Information | https://biobankengine.stanford.edu/RIVAS_HG19/snpnet/INI25851 |
| Score Construction | |
| PGS Name | GBE_INI25851 |
| Development Method | |
| Name | snpnet |
| Parameters | NR |
| Variants | |
| Original Genome Build | GRCh37 |
| Number of Variants | 1,078 |
| Effect Weight Type | NR |
| PGS Source | |
| PGS Catalog Publication (PGP) ID | PGP000244 |
| Citation (link to publication) | Tanigawa Y et al. PLoS Genet (2022) |
| Ancestry Distribution | |
| Score Development/Training | European: 100% 22,320 individuals (100%) |
| PGS Evaluation | European: 40% African: 20% East Asian: 20% South Asian: 20% 5 Sample Sets |
| Study Identifiers | Sample Numbers | Sample Ancestry | Cohort(s) | Phenotype Definitions & Methods | Age of Study Participants | Participant Follow-up Time | Additional Ancestry Description | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| — | 22,320 individuals | European | UKB | — | — | — | white British ancestry | Training + validation cohort (train_val) |
|
PGS Performance Metric ID (PPM) |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|
| PPM006765 | PSS006606| African Ancestry| 200 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Vol. of grey matter in Parahippocampal Gyrus, posterior division (R) | — | — | R²: 0.08591 [0.07289, 0.09893] Incremental R2 (full-covars): -0.02694 PGS R2 (no covariates): 0.0181 [0.01168, 0.02453] |
age, sex, UKB array type, Genotype PCs | — |
| PPM006766 | PSS006607| East Asian Ancestry| 113 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Vol. of grey matter in Parahippocampal Gyrus, posterior division (R) | — | — | R²: 0.12345 [0.09426, 0.15263] Incremental R2 (full-covars): 0.01516 PGS R2 (no covariates): 0.02194 [0.00821, 0.03567] |
age, sex, UKB array type, Genotype PCs | — |
| PPM006767 | PSS006608| European Ancestry| 1,739 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Vol. of grey matter in Parahippocampal Gyrus, posterior division (R) | — | — | R²: 0.13438 [0.12649, 0.14226] Incremental R2 (full-covars): 0.00329 PGS R2 (no covariates): 0.0044 [0.00276, 0.00604] |
age, sex, UKB array type, Genotype PCs | — |
| PPM006768 | PSS006609| South Asian Ancestry| 329 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Vol. of grey matter in Parahippocampal Gyrus, posterior division (R) | — | — | R²: 0.23886 [0.22239, 0.25533] Incremental R2 (full-covars): 0.00802 PGS R2 (no covariates): 0.01564 [0.01019, 0.02109] |
age, sex, UKB array type, Genotype PCs | — |
| PPM006769 | PSS006610| European Ancestry| 5,443 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Vol. of grey matter in Parahippocampal Gyrus, posterior division (R) | — | — | R²: 0.10437 [0.1, 0.10873] Incremental R2 (full-covars): 0.01458 PGS R2 (no covariates): 0.01485 [0.01304, 0.01666] |
age, sex, UKB array type, Genotype PCs | — |
|
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| PSS006606 | — | — | 200 individuals | — | African unspecified | — | UKB | — |
| PSS006607 | — | — | 113 individuals | — | East Asian | — | UKB | — |
| PSS006608 | — | — | 1,739 individuals | — | European | non-white British ancestry | UKB | — |
| PSS006609 | — | — | 329 individuals | — | South Asian | — | UKB | — |
| PSS006610 | — | — | 5,443 individuals | — | European | white British ancestry | UKB | Testing cohort (heldout set) |