| Predicted Trait | |
| Reported Trait | Volume of grey matter in Temporal Fusiform Cortex, posterior division (L) |
| Mapped Trait(s) | |
| Additional Trait Information | https://biobankengine.stanford.edu/RIVAS_HG19/snpnet/INI25856 |
| Score Construction | |
| PGS Name | GBE_INI25856 |
| Development Method | |
| Name | snpnet |
| Parameters | NR |
| Variants | |
| Original Genome Build | GRCh37 |
| Number of Variants | 1,533 |
| Effect Weight Type | NR |
| PGS Source | |
| PGS Catalog Publication (PGP) ID | PGP000244 |
| Citation (link to publication) | Tanigawa Y et al. PLoS Genet (2022) |
| Ancestry Distribution | |
| Score Development/Training | European: 100% 22,320 individuals (100%) |
| PGS Evaluation | European: 40% African: 20% East Asian: 20% South Asian: 20% 5 Sample Sets |
| Study Identifiers | Sample Numbers | Sample Ancestry | Cohort(s) | Phenotype Definitions & Methods | Age of Study Participants | Participant Follow-up Time | Additional Ancestry Description | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| — | 22,320 individuals | European | UKB | — | — | — | white British ancestry | Training + validation cohort (train_val) |
|
PGS Performance Metric ID (PPM) |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|
| PPM006780 | PSS006621| African Ancestry| 200 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Vol. of grey matter in Temporal Fusiform Cortex, posterior division (L) | — | — | R²: 0.1999 [0.18251, 0.21729] Incremental R2 (full-covars): 0.00199 PGS R2 (no covariates): 0.0014 [-0.00042, 0.00322] |
age, sex, UKB array type, Genotype PCs | — |
| PPM006781 | PSS006622| East Asian Ancestry| 113 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Vol. of grey matter in Temporal Fusiform Cortex, posterior division (L) | — | — | R²: 0.25745 [0.22175, 0.29316] Incremental R2 (full-covars): -0.00965 PGS R2 (no covariates): 5e-05 [-0.00061, 0.0007] |
age, sex, UKB array type, Genotype PCs | — |
| PPM006782 | PSS006623| European Ancestry| 1,739 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Vol. of grey matter in Temporal Fusiform Cortex, posterior division (L) | — | — | R²: 0.25532 [0.24598, 0.26467] Incremental R2 (full-covars): 0.01348 PGS R2 (no covariates): 0.01087 [0.00831, 0.01343] |
age, sex, UKB array type, Genotype PCs | — |
| PPM006783 | PSS006624| South Asian Ancestry| 329 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Vol. of grey matter in Temporal Fusiform Cortex, posterior division (L) | — | — | R²: 0.24123 [0.22473, 0.25773] Incremental R2 (full-covars): -0.0026 PGS R2 (no covariates): 0.00704 [0.00335, 0.01072] |
age, sex, UKB array type, Genotype PCs | — |
| PPM006784 | PSS006625| European Ancestry| 5,443 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: Vol. of grey matter in Temporal Fusiform Cortex, posterior division (L) | — | — | R²: 0.20043 [0.19503, 0.20584] Incremental R2 (full-covars): 0.01355 PGS R2 (no covariates): 0.01296 [0.01126, 0.01466] |
age, sex, UKB array type, Genotype PCs | — |
|
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| PSS006621 | — | — | 200 individuals | — | African unspecified | — | UKB | — |
| PSS006622 | — | — | 113 individuals | — | East Asian | — | UKB | — |
| PSS006623 | — | — | 1,739 individuals | — | European | non-white British ancestry | UKB | — |
| PSS006624 | — | — | 329 individuals | — | South Asian | — | UKB | — |
| PSS006625 | — | — | 5,443 individuals | — | European | white British ancestry | UKB | Testing cohort (heldout set) |