| Predicted Trait | |
| Reported Trait | WA ICVF in tract inferior fronto-occipital fasciculus (L) |
| Mapped Trait(s) | |
| Additional Trait Information | https://biobankengine.stanford.edu/RIVAS_HG19/snpnet/INI25662 |
| Score Construction | |
| PGS Name | GBE_INI25662 |
| Development Method | |
| Name | snpnet |
| Parameters | NR |
| Variants | |
| Original Genome Build | GRCh37 |
| Number of Variants | 2,008 |
| Effect Weight Type | NR |
| PGS Source | |
| PGS Catalog Publication (PGP) ID | PGP000244 |
| Citation (link to publication) | Tanigawa Y et al. PLoS Genet (2022) |
| Ancestry Distribution | |
| Score Development/Training | European: 100% 21,080 individuals (100%) |
| PGS Evaluation | European: 40% African: 20% East Asian: 20% South Asian: 20% 5 Sample Sets |
| Study Identifiers | Sample Numbers | Sample Ancestry | Cohort(s) | Phenotype Definitions & Methods | Age of Study Participants | Participant Follow-up Time | Additional Ancestry Description | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| — | 21,080 individuals | European | UKB | — | — | — | white British ancestry | Training + validation cohort (train_val) |
|
PGS Performance Metric ID (PPM) |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|
| PPM006415 | PSS006251| African Ancestry| 182 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: WA ICVF in tract inferior fronto-occipital fasciculus (L) | — | — | R²: 0.07199 [0.05989, 0.08409] Incremental R2 (full-covars): -0.01984 PGS R2 (no covariates): 0.00034 [-0.00056, 0.00124] |
age, sex, UKB array type, Genotype PCs | — |
| PPM006416 | PSS006252| East Asian Ancestry| 106 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: WA ICVF in tract inferior fronto-occipital fasciculus (L) | — | — | R²: 0.14201 [0.11137, 0.17265] Incremental R2 (full-covars): 0.05728 PGS R2 (no covariates): 0.05468 [0.03373, 0.07562] |
age, sex, UKB array type, Genotype PCs | — |
| PPM006417 | PSS006253| European Ancestry| 1,651 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: WA ICVF in tract inferior fronto-occipital fasciculus (L) | — | — | R²: 0.18004 [0.1714, 0.18868] Incremental R2 (full-covars): 0.06558 PGS R2 (no covariates): 0.05754 [0.05192, 0.06315] |
age, sex, UKB array type, Genotype PCs | — |
| PPM006418 | PSS006254| South Asian Ancestry| 299 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: WA ICVF in tract inferior fronto-occipital fasciculus (L) | — | — | R²: 0.0941 [0.0818, 0.10641] Incremental R2 (full-covars): 0.03611 PGS R2 (no covariates): 0.03616 [0.02805, 0.04428] |
age, sex, UKB array type, Genotype PCs | — |
| PPM006419 | PSS006255| European Ancestry| 5,120 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: WA ICVF in tract inferior fronto-occipital fasciculus (L) | — | — | R²: 0.1231 [0.11845, 0.12774] Incremental R2 (full-covars): 0.04943 PGS R2 (no covariates): 0.0479 [0.04476, 0.05105] |
age, sex, UKB array type, Genotype PCs | — |
|
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| PSS006251 | — | — | 182 individuals | — | African unspecified | — | UKB | — |
| PSS006252 | — | — | 106 individuals | — | East Asian | — | UKB | — |
| PSS006253 | — | — | 1,651 individuals | — | European | non-white British ancestry | UKB | — |
| PSS006254 | — | — | 299 individuals | — | South Asian | — | UKB | — |
| PSS006255 | — | — | 5,120 individuals | — | European | white British ancestry | UKB | Testing cohort (heldout set) |