| Predicted Trait | |
| Reported Trait | WA ICVF in tract inferior fronto-occipital fasciculus (R) |
| Mapped Trait(s) | |
| Additional Trait Information | https://biobankengine.stanford.edu/RIVAS_HG19/snpnet/INI25663 |
| Score Construction | |
| PGS Name | GBE_INI25663 |
| Development Method | |
| Name | snpnet |
| Parameters | NR |
| Variants | |
| Original Genome Build | GRCh37 |
| Number of Variants | 1,964 |
| Effect Weight Type | NR |
| PGS Source | |
| PGS Catalog Publication (PGP) ID | PGP000244 |
| Citation (link to publication) | Tanigawa Y et al. PLoS Genet (2022) |
| Ancestry Distribution | |
| Score Development/Training | European: 100% 21,080 individuals (100%) |
| PGS Evaluation | European: 40% African: 20% East Asian: 20% South Asian: 20% 5 Sample Sets |
| Study Identifiers | Sample Numbers | Sample Ancestry | Cohort(s) | Phenotype Definitions & Methods | Age of Study Participants | Participant Follow-up Time | Additional Ancestry Description | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| — | 21,080 individuals | European | UKB | — | — | — | white British ancestry | Training + validation cohort (train_val) |
|
PGS Performance Metric ID (PPM) |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|
| PPM006420 | PSS006256| African Ancestry| 182 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: WA ICVF in tract inferior fronto-occipital fasciculus (R) | — | — | R²: 0.07389 [0.06165, 0.08613] Incremental R2 (full-covars): -0.00027 PGS R2 (no covariates): 0.00573 [0.00207, 0.00939] |
age, sex, UKB array type, Genotype PCs | — |
| PPM006421 | PSS006257| East Asian Ancestry| 106 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: WA ICVF in tract inferior fronto-occipital fasciculus (R) | — | — | R²: 0.12751 [0.09798, 0.15703] Incremental R2 (full-covars): 0.02934 PGS R2 (no covariates): 0.02719 [0.01199, 0.04239] |
age, sex, UKB array type, Genotype PCs | — |
| PPM006422 | PSS006258| European Ancestry| 1,651 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: WA ICVF in tract inferior fronto-occipital fasciculus (R) | — | — | R²: 0.15899 [0.15067, 0.16732] Incremental R2 (full-covars): 0.05575 PGS R2 (no covariates): 0.04899 [0.04376, 0.05422] |
age, sex, UKB array type, Genotype PCs | — |
| PPM006423 | PSS006259| South Asian Ancestry| 299 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: WA ICVF in tract inferior fronto-occipital fasciculus (R) | — | — | R²: 0.07916 [0.06768, 0.09063] Incremental R2 (full-covars): 0.03126 PGS R2 (no covariates): 0.03059 [0.02308, 0.0381] |
age, sex, UKB array type, Genotype PCs | — |
| PPM006424 | PSS006260| European Ancestry| 5,120 individuals |
PGP000244 | Tanigawa Y et al. PLoS Genet (2022) |
Reported Trait: WA ICVF in tract inferior fronto-occipital fasciculus (R) | — | — | R²: 0.11949 [0.1149, 0.12409] Incremental R2 (full-covars): 0.04903 PGS R2 (no covariates): 0.04898 [0.0458, 0.05216] |
age, sex, UKB array type, Genotype PCs | — |
|
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| PSS006256 | — | — | 182 individuals | — | African unspecified | — | UKB | — |
| PSS006257 | — | — | 106 individuals | — | East Asian | — | UKB | — |
| PSS006258 | — | — | 1,651 individuals | — | European | non-white British ancestry | UKB | — |
| PSS006259 | — | — | 299 individuals | — | South Asian | — | UKB | — |
| PSS006260 | — | — | 5,120 individuals | — | European | white British ancestry | UKB | Testing cohort (heldout set) |