Polygenic Score (PGS) ID: PGS001795

Predicted Trait
Reported Trait Uterine cancer
Mapped Trait(s) uterine carcinoma (EFO_0002919)
Released in PGS Catalog: Sept. 8, 2022
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Score Details

Score Construction
PGS Name 1kgeur_gbmi_leaveUKBBout_UtC_pst_eff_a1_b0.5_phiauto
Development Method
Name PRS-CS-auto
Parameters effective sample size and other defualt parameters
Variants
Original Genome Build GRCh37
Number of Variants 911,692
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000262
Citation (link to publication) Wang Y et al. Cell Genom (2023)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 83.9%
East Asian: 15.2%
Additional Diverse Ancestries: 0.8%
692,891 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
—
[
  • 83 cases
  • , 5,786 controls
]
 Native American BioMe
—
[
  • 1,364 cases
  • , 104,200 controls
]
 East Asian BBJ, CKB
—
[
  • 6,848 cases
  • , 574,610 controls
]
 European 8 cohorts
  • BioVU
  • ,CCPM
  • ,EB
  • ,FinnGen
  • ,HUNT
  • ,MGBB
  • ,MGI
  • ,deCODE

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM009299 PSS007718|
European Ancestry|
170,276 individuals
 PGP000262 |
Wang Y et al. Cell Genom (2023)
 Reported Trait: Uterine cancer — AUROC: 0.66 Nagelkerke's R2 (covariates regressed out): 0.00195 sex,age,age2,age*sex,age^2*sex, 20PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS007718 — —
[
  • 1,323 cases
  • , 168,952 controls
]
 — European — UKB —