Predicted Trait | |
Reported Trait | Thyroid cancer |
Mapped Trait(s) | thyroid carcinoma (EFO_0002892) |
Additional Trait Information | neoplasms |
Score Construction | |
PGS Name | portability-PLR_193 |
Development Method | |
Name | Penalized regression (bigstatsr) |
Parameters | HapMap3 variants |
Variants | |
Original Genome Build | GRCh37 |
Number of Variants | 111 |
Effect Weight Type | beta |
PGS Source | |
PGS Catalog Publication (PGP) ID | PGP000263 |
Citation (link to publication) | Privé F et al. Am J Hum Genet (2022) |
Study Identifiers | Sample Numbers | Sample Ancestry | Cohort(s) | Phenotype Definitions & Methods | Age of Study Participants | Participant Follow-up Time | Additional Ancestry Description | Additional Sample/Cohort Information |
---|---|---|---|---|---|---|---|---|
— | 391,124 individuals | European | UKB | — | — | — | UK (+ Ireland) | — |
PGS Performance Metric ID (PPM) |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
---|---|---|---|---|---|---|---|---|
PPM009374 | PSS009279| European Ancestry| 19,923 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Thyroid cancer | — | — | Partial Correlation (partial-r): 0.0307 [0.0168, 0.0446] | sex, age, birth date, deprivation index, 16 PCs | — |
PPM009377 | PSS008383| Greater Middle Eastern Ancestry| 1,197 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Thyroid cancer | — | — | Partial Correlation (partial-r): -0.0014 [-0.0586, 0.0557] | sex, age, birth date, deprivation index, 16 PCs | — |
PPM009378 | PSS008161| South Asian Ancestry| 6,305 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Thyroid cancer | — | — | Partial Correlation (partial-r): 0.0052 [-0.0195, 0.0299] | sex, age, birth date, deprivation index, 16 PCs | — |
PPM009379 | PSS007948| East Asian Ancestry| 1,801 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Thyroid cancer | — | — | Partial Correlation (partial-r): -0.0121 [-0.0585, 0.0344] | sex, age, birth date, deprivation index, 16 PCs | — |
PPM009380 | PSS007730| African Ancestry| 2,453 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Thyroid cancer | — | — | Partial Correlation (partial-r): 0.0102 [-0.0296, 0.0499] | sex, age, birth date, deprivation index, 16 PCs | — |
PPM009381 | PSS008833| African Ancestry| 3,896 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Thyroid cancer | — | — | Partial Correlation (partial-r): 0.0008 [-0.0307, 0.0323] | sex, age, birth date, deprivation index, 16 PCs | — |
PPM009375 | PSS009053| European Ancestry| 4,120 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Thyroid cancer | — | — | Partial Correlation (partial-r): -0.0082 [-0.0388, 0.0225] | sex, age, birth date, deprivation index, 16 PCs | — |
PPM009376 | PSS008607| European Ancestry| 6,640 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Thyroid cancer | — | — | Partial Correlation (partial-r): 0.0196 [-0.0045, 0.0437] | sex, age, birth date, deprivation index, 16 PCs | — |
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
---|---|---|---|---|---|---|---|---|
PSS008833 | — | — | 3,896 individuals | — | African unspecified | Nigeria (West Africa) | UKB | — |
PSS007948 | — | — | 1,801 individuals | — | East Asian | China (East Asia) | UKB | — |
PSS007730 | — | — | 2,453 individuals | — | African American or Afro-Caribbean | Carribean | UKB | — |
PSS008383 | — | — | 1,197 individuals | — | Greater Middle Eastern (Middle Eastern, North African or Persian) | Iran (Middle East) | UKB | — |
PSS008607 | — | — | 6,640 individuals | — | European | Italy (South Europe) | UKB | — |
PSS009053 | — | — | 4,120 individuals | — | European | Poland (NE Europe) | UKB | — |
PSS009279 | — | — | 19,923 individuals | — | European | UK (+ Ireland) | UKB | — |
PSS008161 | — | — | 6,305 individuals | — | South Asian | India (South Asia) | UKB | — |