Polygenic Score (PGS) ID: PGS001914

Predicted Trait
Reported Trait Testosterone (female only)
Mapped Trait(s)
Additional Trait Information biological measures
Released in PGS Catalog: Jan. 10, 2022
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Score Details

Score Construction
PGS Name portability-PLR_F_log_testosterone
Development Method
Name Penalized regression (bigstatsr)
Parameters HapMap3 variants
Variants
Original Genome Build GRCh37
Number of Variants 18,179
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000263
Citation (link to publication) Privé F et al. Am J Hum Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
391,124 individuals (100%)
PGS Evaluation
European: 37.5%
African: 25%
East Asian: 12.5%
Greater Middle Eastern: 12.5%
South Asian: 12.5%
8 Sample Sets

Development Samples

Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 391,124 individuals European UKB — — — UK (+ Ireland) —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM010195 PSS009374|
European Ancestry|
9,296 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Testosterone (female only) — — Partial Correlation (partial-r): 0.1628 [0.143, 0.1826] sex, age, birth date, deprivation index, 16 PCs —
PPM010197 PSS008702|
European Ancestry|
3,123 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Testosterone (female only) — — Partial Correlation (partial-r): 0.1116 [0.0767, 0.1462] sex, age, birth date, deprivation index, 16 PCs —
PPM010198 PSS008476|
Greater Middle Eastern Ancestry|
562 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Testosterone (female only) — — Partial Correlation (partial-r): 0.2041 [0.122, 0.2835] sex, age, birth date, deprivation index, 16 PCs —
PPM010199 PSS008254|
South Asian Ancestry|
2,976 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Testosterone (female only) — — Partial Correlation (partial-r): 0.1494 [0.114, 0.1845] sex, age, birth date, deprivation index, 16 PCs —
PPM010200 PSS008032|
East Asian Ancestry|
855 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Testosterone (female only) — — Partial Correlation (partial-r): 0.0621 [-0.0058, 0.1294] sex, age, birth date, deprivation index, 16 PCs —
PPM010201 PSS007818|
African Ancestry|
1,112 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Testosterone (female only) — — Partial Correlation (partial-r): 0.0967 [0.0376, 0.1551] sex, age, birth date, deprivation index, 16 PCs —
PPM010202 PSS008922|
African Ancestry|
1,808 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Testosterone (female only) — — Partial Correlation (partial-r): 0.0739 [0.0276, 0.1198] sex, age, birth date, deprivation index, 16 PCs —
PPM010196 PSS009148|
European Ancestry|
1,918 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Testosterone (female only) — — Partial Correlation (partial-r): 0.1364 [0.092, 0.1803] sex, age, birth date, deprivation index, 16 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS008254 — — 2,976 individuals — South Asian India (South Asia) UKB —
PSS007818 — — 1,112 individuals — African American or Afro-Caribbean Carribean UKB —
PSS009148 — — 1,918 individuals — European Poland (NE Europe) UKB —
PSS008702 — — 3,123 individuals — European Italy (South Europe) UKB —
PSS008922 — — 1,808 individuals — African unspecified Nigeria (West Africa) UKB —
PSS008476 — — 562 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS009374 — — 9,296 individuals — European UK (+ Ireland) UKB —
PSS008032 — — 855 individuals — East Asian China (East Asia) UKB —