Polygenic Score (PGS) ID: PGS001942

Predicted Trait
Reported Trait Total bilirubin
Mapped Trait(s) bilirubin measurement (EFO_0004570)
Additional Trait Information biological measures
Released in PGS Catalog: Jan. 10, 2022
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Score Details

Score Construction
PGS Name portability-PLR_log_bilirubin
Development Method
Name Penalized regression (bigstatsr)
Parameters HapMap3 variants
Variants
Original Genome Build GRCh37
Number of Variants 33,190
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000263
Citation (link to publication) Privé F et al. Am J Hum Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
391,124 individuals (100%)
PGS Evaluation
European: 37.5%
African: 25%
East Asian: 12.5%
Greater Middle Eastern: 12.5%
South Asian: 12.5%
8 Sample Sets

Development Samples

Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 391,124 individuals European UKB — — — UK (+ Ireland) —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM010411 PSS009438|
European Ancestry|
18,919 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Total bilirubin — — Partial Correlation (partial-r): 0.6051 [0.596, 0.6141] sex, age, birth date, deprivation index, 16 PCs —
PPM010412 PSS009212|
European Ancestry|
3,930 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Total bilirubin — — Partial Correlation (partial-r): 0.6191 [0.5993, 0.638] sex, age, birth date, deprivation index, 16 PCs —
PPM010413 PSS008766|
European Ancestry|
6,303 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Total bilirubin — — Partial Correlation (partial-r): 0.6087 [0.5929, 0.624] sex, age, birth date, deprivation index, 16 PCs —
PPM010414 PSS008540|
Greater Middle Eastern Ancestry|
1,120 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Total bilirubin — — Partial Correlation (partial-r): 0.5648 [0.5231, 0.6037] sex, age, birth date, deprivation index, 16 PCs —
PPM010415 PSS008318|
South Asian Ancestry|
5,983 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Total bilirubin — — Partial Correlation (partial-r): 0.5812 [0.5641, 0.5977] sex, age, birth date, deprivation index, 16 PCs —
PPM010416 PSS008095|
East Asian Ancestry|
1,702 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Total bilirubin — — Partial Correlation (partial-r): 0.4145 [0.3742, 0.4534] sex, age, birth date, deprivation index, 16 PCs —
PPM010417 PSS007882|
African Ancestry|
2,326 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Total bilirubin — — Partial Correlation (partial-r): 0.5368 [0.5071, 0.5653] sex, age, birth date, deprivation index, 16 PCs —
PPM010418 PSS008986|
African Ancestry|
3,640 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Total bilirubin — — Partial Correlation (partial-r): 0.5462 [0.5229, 0.5686] sex, age, birth date, deprivation index, 16 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS008540 — — 1,120 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS007882 — — 2,326 individuals — African American or Afro-Caribbean Carribean UKB —
PSS008318 — — 5,983 individuals — South Asian India (South Asia) UKB —
PSS008766 — — 6,303 individuals — European Italy (South Europe) UKB —
PSS008986 — — 3,640 individuals — African unspecified Nigeria (West Africa) UKB —
PSS009212 — — 3,930 individuals — European Poland (NE Europe) UKB —
PSS009438 — — 18,919 individuals — European UK (+ Ireland) UKB —
PSS008095 — — 1,702 individuals — East Asian China (East Asia) UKB —