PGS Catalog - PGS001960 / IGF-1 (Polygenic Score)

Polygenic Score (PGS) ID: PGS001960

Predicted Trait
Reported Trait	IGF-1
Mapped Trait(s)	IGF-1 measurement (EFO_0004627)
Additional Trait Information	biological measures

Released in PGS Catalog: Jan. 10, 2022

Download Score FTP directory

Terms and Licenses

PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name	portability-PLR_log_IGF1
Development Method
Name	Penalized regression (bigstatsr)
Parameters	HapMap3 variants
Variants
Original Genome Build	GRCh37
Number of Variants	87,149
Effect Weight Type	beta

PGS Source
PGS Catalog Publication (PGP) ID	PGP000263
Citation (link to publication)	Privé F et al. Am J Hum Genet (2022)

Ancestry Distribution
Score Development/Training	European: 100% 391,124 individuals (100%)
PGS Evaluation	European: 37.5% African: 25% East Asian: 12.5% Greater Middle Eastern: 12.5% South Asian: 12.5% 8 Sample Sets

Development Samples

Score Development/Training

Loading, please wait

Study Identifiers	Sample Numbers	Sample Ancestry	Cohort(s)	Phenotype Definitions & Methods	Age of Study Participants	Participant Follow-up Time	Additional Ancestry Description	Additional Sample/Cohort Information
—	391,124 individuals	European	UKB	—	—	—	UK (+ Ireland)	—

Showing 1 to 1 of 1 rows

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

Loading, please wait

PGS Performance Metric ID (PPM)	PGS Sample Set ID (PSS)	Performance Source	Trait	PGS Effect Sizes (per SD change)	Classification Metrics	Other Metrics	Covariates Included in the Model	PGS Performance: Other Relevant Information
PPM010555	PSS009435\| European Ancestry\| 18,901 individuals	PGP000263 \| Privé F et al. Am J Hum Genet (2022)	Reported Trait: IGF-1	—	—	Partial Correlation (partial-r): 0.3977 [0.3856, 0.4096]	sex, age, birth date, deprivation index, 16 PCs	—
PPM010556	PSS009209\| European Ancestry\| 3,935 individuals	PGP000263 \| Privé F et al. Am J Hum Genet (2022)	Reported Trait: IGF-1	—	—	Partial Correlation (partial-r): 0.3641 [0.3366, 0.391]	sex, age, birth date, deprivation index, 16 PCs	—
PPM010557	PSS008763\| European Ancestry\| 6,290 individuals	PGP000263 \| Privé F et al. Am J Hum Genet (2022)	Reported Trait: IGF-1	—	—	Partial Correlation (partial-r): 0.3719 [0.3503, 0.393]	sex, age, birth date, deprivation index, 16 PCs	—
PPM010558	PSS008537\| Greater Middle Eastern Ancestry\| 1,118 individuals	PGP000263 \| Privé F et al. Am J Hum Genet (2022)	Reported Trait: IGF-1	—	—	Partial Correlation (partial-r): 0.3755 [0.3236, 0.4253]	sex, age, birth date, deprivation index, 16 PCs	—
PPM010559	PSS008315\| South Asian Ancestry\| 5,961 individuals	PGP000263 \| Privé F et al. Am J Hum Genet (2022)	Reported Trait: IGF-1	—	—	Partial Correlation (partial-r): 0.3361 [0.3134, 0.3585]	sex, age, birth date, deprivation index, 16 PCs	—
PPM010560	PSS008092\| East Asian Ancestry\| 1,710 individuals	PGP000263 \| Privé F et al. Am J Hum Genet (2022)	Reported Trait: IGF-1	—	—	Partial Correlation (partial-r): 0.2886 [0.2443, 0.3317]	sex, age, birth date, deprivation index, 16 PCs	—
PPM010561	PSS007879\| African Ancestry\| 2,328 individuals	PGP000263 \| Privé F et al. Am J Hum Genet (2022)	Reported Trait: IGF-1	—	—	Partial Correlation (partial-r): 0.1917 [0.1521, 0.2307]	sex, age, birth date, deprivation index, 16 PCs	—
PPM010562	PSS008983\| African Ancestry\| 3,637 individuals	PGP000263 \| Privé F et al. Am J Hum Genet (2022)	Reported Trait: IGF-1	—	—	Partial Correlation (partial-r): 0.2039 [0.1725, 0.2349]	sex, age, birth date, deprivation index, 16 PCs	—

Showing 1 to 8 of 8 rows

Evaluated Samples

Loading, please wait

PGS Sample Set ID (PSS)	Phenotype Definitions and Methods	Participant Follow-up Time	Sample Numbers	Age of Study Participants	Sample Ancestry	Additional Ancestry Description	Cohort(s)	Additional Sample/Cohort Information
PSS007879	—	—	2,328 individuals	—	African American or Afro-Caribbean	Carribean	UKB	—
PSS008092	—	—	1,710 individuals	—	East Asian	China (East Asia)	UKB	—
PSS008315	—	—	5,961 individuals	—	South Asian	India (South Asia)	UKB	—
PSS008537	—	—	1,118 individuals	—	Greater Middle Eastern (Middle Eastern, North African or Persian)	Iran (Middle East)	UKB	—
PSS008763	—	—	6,290 individuals	—	European	Italy (South Europe)	UKB	—
PSS008983	—	—	3,637 individuals	—	African unspecified	Nigeria (West Africa)	UKB	—
PSS009209	—	—	3,935 individuals	—	European	Poland (NE Europe)	UKB	—
PSS009435	—	—	18,901 individuals	—	European	UK (+ Ireland)	UKB	—

Showing 1 to 8 of 8 rows