Polygenic Score (PGS) ID: PGS001974

Predicted Trait
Reported Trait Potassium in urine
Mapped Trait(s) urinary potassium measurement (EFO_0010952)
Additional Trait Information biological measures
Released in PGS Catalog: Jan. 10, 2022
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Score Details

Score Construction
PGS Name portability-PLR_log_potassium_urine
Development Method
Name Penalized regression (bigstatsr)
Parameters HapMap3 variants
Variants
Original Genome Build GRCh37
Number of Variants 21,512
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000263
Citation (link to publication) Privé F et al. Am J Hum Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
391,124 individuals (100%)
PGS Evaluation
European: 37.5%
African: 25%
East Asian: 12.5%
Greater Middle Eastern: 12.5%
South Asian: 12.5%
8 Sample Sets

Development Samples

Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 391,124 individuals European UKB — — — UK (+ Ireland) —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM010667 PSS009463|
European Ancestry|
19,363 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Potassium in urine — — Partial Correlation (partial-r): 0.0706 [0.0565, 0.0846] sex, age, birth date, deprivation index, 16 PCs —
PPM010668 PSS009237|
European Ancestry|
3,970 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Potassium in urine — — Partial Correlation (partial-r): 0.0851 [0.0541, 0.116] sex, age, birth date, deprivation index, 16 PCs —
PPM010669 PSS008791|
European Ancestry|
6,432 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Potassium in urine — — Partial Correlation (partial-r): 0.0709 [0.0465, 0.0952] sex, age, birth date, deprivation index, 16 PCs —
PPM010671 PSS008343|
South Asian Ancestry|
6,020 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Potassium in urine — — Partial Correlation (partial-r): 0.0626 [0.0373, 0.0877] sex, age, birth date, deprivation index, 16 PCs —
PPM010672 PSS008120|
East Asian Ancestry|
1,743 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Potassium in urine — — Partial Correlation (partial-r): 0.0368 [-0.0104, 0.0839] sex, age, birth date, deprivation index, 16 PCs —
PPM010673 PSS007907|
African Ancestry|
2,382 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Potassium in urine — — Partial Correlation (partial-r): 0.0381 [-0.0022, 0.0783] sex, age, birth date, deprivation index, 16 PCs —
PPM010674 PSS009011|
African Ancestry|
3,772 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Potassium in urine — — Partial Correlation (partial-r): 0.0225 [-0.0095, 0.0545] sex, age, birth date, deprivation index, 16 PCs —
PPM010670 PSS008565|
Greater Middle Eastern Ancestry|
1,146 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Potassium in urine — — Partial Correlation (partial-r): 0.0884 [0.0302, 0.1461] sex, age, birth date, deprivation index, 16 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009011 — — 3,772 individuals — African unspecified Nigeria (West Africa) UKB —
PSS009237 — — 3,970 individuals — European Poland (NE Europe) UKB —
PSS008565 — — 1,146 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS009463 — — 19,363 individuals — European UK (+ Ireland) UKB —
PSS008791 — — 6,432 individuals — European Italy (South Europe) UKB —
PSS008343 — — 6,020 individuals — South Asian India (South Asia) UKB —
PSS008120 — — 1,743 individuals — East Asian China (East Asia) UKB —
PSS007907 — — 2,382 individuals — African American or Afro-Caribbean Carribean UKB —