Polygenic Score (PGS) ID: PGS002010

Predicted Trait
Reported Trait Urate
Mapped Trait(s) urate measurement (EFO_0004531)
Additional Trait Information biological measures
Released in PGS Catalog: Jan. 10, 2022
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Score Details

Score Construction
PGS Name portability-PLR_urate
Development Method
Name Penalized regression (bigstatsr)
Parameters HapMap3 variants
Variants
Original Genome Build GRCh37
Number of Variants 75,102
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000263
Citation (link to publication) Privé F et al. Am J Hum Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
391,124 individuals (100%)
PGS Evaluation
European: 37.5%
African: 25%
East Asian: 12.5%
Greater Middle Eastern: 12.5%
South Asian: 12.5%
8 Sample Sets

Development Samples

Score Development/Training
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Study Identifiers
Sample Numbers
Sample Ancestry
Cohort(s)
Phenotype Definitions & Methods
Age of Study Participants
Participant Follow-up Time
Additional Ancestry Description
Additional Sample/Cohort Information
391,124 individualsEuropeanUKBUK (+ Ireland)
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Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

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PGS Performance
Metric ID (PPM)
PGS Sample Set ID
(PSS)
Performance Source
Trait
PGS Effect Sizes
(per SD change)
Classification Metrics
Other Metrics
Covariates Included in the Model
PGS Performance:
Other Relevant Information
PPM010954PSS009495|
European Ancestry|
18,977 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: UratePartial Correlation (partial-r): 0.3885 [0.3763, 0.4005]sex, age, birth date, deprivation index, 16 PCs
PPM010955PSS009269|
European Ancestry|
3,948 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: UratePartial Correlation (partial-r): 0.3794 [0.3523, 0.4058]sex, age, birth date, deprivation index, 16 PCs
PPM010956PSS008823|
European Ancestry|
6,318 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: UratePartial Correlation (partial-r): 0.3878 [0.3666, 0.4086]sex, age, birth date, deprivation index, 16 PCs
PPM010957PSS008597|
Greater Middle Eastern Ancestry|
1,124 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: UratePartial Correlation (partial-r): 0.3602 [0.3077, 0.4104]sex, age, birth date, deprivation index, 16 PCs
PPM010958PSS008375|
South Asian Ancestry|
5,991 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: UratePartial Correlation (partial-r): 0.3429 [0.3203, 0.3651]sex, age, birth date, deprivation index, 16 PCs
PPM010959PSS008151|
East Asian Ancestry|
1,714 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: UratePartial Correlation (partial-r): 0.3222 [0.2788, 0.3642]sex, age, birth date, deprivation index, 16 PCs
PPM010960PSS007939|
African Ancestry|
2,343 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: UratePartial Correlation (partial-r): 0.2409 [0.2022, 0.2789]sex, age, birth date, deprivation index, 16 PCs
PPM010961PSS009043|
African Ancestry|
3,652 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: UratePartial Correlation (partial-r): 0.2438 [0.2129, 0.2741]sex, age, birth date, deprivation index, 16 PCs
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Evaluated Samples

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PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods
Participant Follow-up Time
Sample Numbers
Age of Study Participants
Sample Ancestry
Additional Ancestry Description
Cohort(s)
Additional Sample/Cohort Information
PSS0079392,343 individualsAfrican American or Afro-CaribbeanCarribeanUKB
PSS0081511,714 individualsEast AsianChina (East Asia)UKB
PSS0083755,991 individualsSouth AsianIndia (South Asia)UKB
PSS0085971,124 individualsGreater Middle Eastern (Middle Eastern, North African or Persian)Iran (Middle East)UKB
PSS0088236,318 individualsEuropeanItaly (South Europe)UKB
PSS0090433,652 individualsAfrican unspecifiedNigeria (West Africa)UKB
PSS0092693,948 individualsEuropeanPoland (NE Europe)UKB
PSS00949518,977 individualsEuropeanUK (+ Ireland)UKB
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