Polygenic Score (PGS) ID: PGS002011

Predicted Trait
Reported Trait Water intake
Mapped Trait(s) drinking behavior (EFO_0004315)
Additional Trait Information lifestyle and environment
Released in PGS Catalog: Jan. 10, 2022
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Score Details

Score Construction
PGS Name portability-PLR_water_intake
Development Method
Name Penalized regression (bigstatsr)
Parameters HapMap3 variants
Variants
Original Genome Build GRCh37
Number of Variants 43,709
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000263
Citation (link to publication) Privé F et al. Am J Hum Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
391,124 individuals (100%)
PGS Evaluation
European: 37.5%
African: 25%
East Asian: 12.5%
Greater Middle Eastern: 12.5%
South Asian: 12.5%
8 Sample Sets

Development Samples

Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 391,124 individuals European UKB — — — UK (+ Ireland) —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM010962 PSS009496|
European Ancestry|
19,824 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Water intake — — Partial Correlation (partial-r): 0.1332 [0.1195, 0.1468] sex, age, birth date, deprivation index, 16 PCs —
PPM010963 PSS009270|
European Ancestry|
4,075 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Water intake — — Partial Correlation (partial-r): 0.1224 [0.0919, 0.1526] sex, age, birth date, deprivation index, 16 PCs —
PPM010964 PSS008824|
European Ancestry|
6,552 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Water intake — — Partial Correlation (partial-r): 0.1169 [0.0929, 0.1408] sex, age, birth date, deprivation index, 16 PCs —
PPM010965 PSS008598|
Greater Middle Eastern Ancestry|
1,144 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Water intake — — Partial Correlation (partial-r): 0.1031 [0.0449, 0.1606] sex, age, birth date, deprivation index, 16 PCs —
PPM010966 PSS008376|
South Asian Ancestry|
6,162 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Water intake — — Partial Correlation (partial-r): 0.0895 [0.0646, 0.1142] sex, age, birth date, deprivation index, 16 PCs —
PPM010967 PSS008152|
East Asian Ancestry|
1,760 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Water intake — — Partial Correlation (partial-r): 0.0666 [0.0197, 0.1133] sex, age, birth date, deprivation index, 16 PCs —
PPM010968 PSS007940|
African Ancestry|
2,404 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Water intake — — Partial Correlation (partial-r): 0.0815 [0.0415, 0.1212] sex, age, birth date, deprivation index, 16 PCs —
PPM010969 PSS009044|
African Ancestry|
3,722 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Water intake — — Partial Correlation (partial-r): 0.0064 [-0.0258, 0.0386] sex, age, birth date, deprivation index, 16 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS007940 — — 2,404 individuals — African American or Afro-Caribbean Carribean UKB —
PSS009044 — — 3,722 individuals — African unspecified Nigeria (West Africa) UKB —
PSS008598 — — 1,144 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS009270 — — 4,075 individuals — European Poland (NE Europe) UKB —
PSS008824 — — 6,552 individuals — European Italy (South Europe) UKB —
PSS008376 — — 6,162 individuals — South Asian India (South Asia) UKB —
PSS009496 — — 19,824 individuals — European UK (+ Ireland) UKB —
PSS008152 — — 1,760 individuals — East Asian China (East Asia) UKB —