Predicted Trait | |
Reported Trait | Hypothyroidism |
Mapped Trait(s) | hypothyroidism (EFO_0004705) |
Additional Trait Information | endocrine/metabolic |
Score Construction | |
PGS Name | portability-ldpred2_244 |
Development Method | |
Name | LDpred2 (bigsnpr) |
Parameters | LDpred2-auto using HapMap3 variants |
Variants | |
Original Genome Build | GRCh37 |
Number of Variants | 632,597 |
Effect Weight Type | beta |
PGS Source | |
PGS Catalog Publication (PGP) ID | PGP000263 |
Citation (link to publication) | Privé F et al. Am J Hum Genet (2022) |
Study Identifiers | Sample Numbers | Sample Ancestry | Cohort(s) | Phenotype Definitions & Methods | Age of Study Participants | Participant Follow-up Time | Additional Ancestry Description | Additional Sample/Cohort Information |
---|---|---|---|---|---|---|---|---|
— | 391,124 individuals | European | UKB | — | — | — | UK (+ Ireland) | — |
PGS Performance Metric ID (PPM) |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
---|---|---|---|---|---|---|---|---|
PPM011066 | PSS009286| European Ancestry| 19,852 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Hypothyroidism | — | — | Partial Correlation (partial-r): 0.122 [0.1083, 0.1357] | sex, age, birth date, deprivation index, 16 PCs | — |
PPM011067 | PSS009060| European Ancestry| 4,100 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Hypothyroidism | — | — | Partial Correlation (partial-r): 0.143 [0.1128, 0.1729] | sex, age, birth date, deprivation index, 16 PCs | — |
PPM011068 | PSS008614| European Ancestry| 6,601 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Hypothyroidism | — | — | Partial Correlation (partial-r): 0.1035 [0.0795, 0.1273] | sex, age, birth date, deprivation index, 16 PCs | — |
PPM011069 | PSS008390| Greater Middle Eastern Ancestry| 1,186 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Hypothyroidism | — | — | Partial Correlation (partial-r): 0.133 [0.0762, 0.189] | sex, age, birth date, deprivation index, 16 PCs | — |
PPM011070 | PSS008168| South Asian Ancestry| 6,272 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Hypothyroidism | — | — | Partial Correlation (partial-r): 0.1186 [0.094, 0.1429] | sex, age, birth date, deprivation index, 16 PCs | — |
PPM011071 | PSS007955| East Asian Ancestry| 1,782 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Hypothyroidism | — | — | Partial Correlation (partial-r): 0.047 | sex, age, birth date, deprivation index, 16 PCs | — |
PPM011072 | PSS007736| African Ancestry| 2,434 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Hypothyroidism | — | — | Partial Correlation (partial-r): 0.0093 [-0.0306, 0.0492] | sex, age, birth date, deprivation index, 16 PCs | — |
PPM011073 | PSS008839| African Ancestry| 3,876 individuals |
PGP000263 | Privé F et al. Am J Hum Genet (2022) |
Reported Trait: Hypothyroidism | — | — | Partial Correlation (partial-r): 0.0396 [0.0081, 0.0711] | sex, age, birth date, deprivation index, 16 PCs | — |
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
---|---|---|---|---|---|---|---|---|
PSS009060 | — | — | 4,100 individuals | — | European | Poland (NE Europe) | UKB | — |
PSS008614 | — | — | 6,601 individuals | — | European | Italy (South Europe) | UKB | — |
PSS009286 | — | — | 19,852 individuals | — | European | UK (+ Ireland) | UKB | — |
PSS008390 | — | — | 1,186 individuals | — | Greater Middle Eastern (Middle Eastern, North African or Persian) | Iran (Middle East) | UKB | — |
PSS008168 | — | — | 6,272 individuals | — | South Asian | India (South Asia) | UKB | — |
PSS008839 | — | — | 3,876 individuals | — | African unspecified | Nigeria (West Africa) | UKB | — |
PSS007955 | — | — | 1,782 individuals | — | East Asian | China (East Asia) | UKB | — |
PSS007736 | — | — | 2,434 individuals | — | African American or Afro-Caribbean | Carribean | UKB | — |