Polygenic Score (PGS) ID: PGS002028

Predicted Trait
Reported Trait Hypoglycemia
Mapped Trait(s) Hypoglycemia (HP_0001943)
Additional Trait Information endocrine/metabolic
Released in PGS Catalog: Jan. 10, 2022
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Score Details

Score Construction
PGS Name portability-ldpred2_251.1
Development Method
Name LDpred2 (bigsnpr)
Parameters LDpred2-auto using HapMap3 variants
Variants
Original Genome Build GRCh37
Number of Variants 170,554
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000263
Citation (link to publication) Privé F et al. Am J Hum Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
391,124 individuals (100%)
PGS Evaluation
European: 37.5%
African: 25%
East Asian: 12.5%
Greater Middle Eastern: 12.5%
South Asian: 12.5%
8 Sample Sets

Development Samples

Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 391,124 individuals European UKB — — — UK (+ Ireland) —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM011098 PSS009290|
European Ancestry|
18,689 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Hypoglycemia — — Partial Correlation (partial-r): 0.0307 [0.0163, 0.045] sex, age, birth date, deprivation index, 16 PCs —
PPM011099 PSS009064|
European Ancestry|
3,905 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Hypoglycemia — — Partial Correlation (partial-r): 0.0136 [-0.0178, 0.0451] sex, age, birth date, deprivation index, 16 PCs —
PPM011100 PSS008618|
European Ancestry|
6,237 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Hypoglycemia — — Partial Correlation (partial-r): 0.0147 [-0.0101, 0.0396] sex, age, birth date, deprivation index, 16 PCs —
PPM011101 PSS008394|
Greater Middle Eastern Ancestry|
1,092 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Hypoglycemia — — Partial Correlation (partial-r): 0.0189 [-0.041, 0.0787] sex, age, birth date, deprivation index, 16 PCs —
PPM011102 PSS008172|
South Asian Ancestry|
5,103 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Hypoglycemia — — Partial Correlation (partial-r): 0.0134 [-0.0141, 0.0408] sex, age, birth date, deprivation index, 16 PCs —
PPM011103 PSS007959|
East Asian Ancestry|
1,714 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Hypoglycemia — — Partial Correlation (partial-r): -0.0153 [-0.0629, 0.0323] sex, age, birth date, deprivation index, 16 PCs —
PPM011104 PSS007740|
African Ancestry|
2,147 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Hypoglycemia — — Partial Correlation (partial-r): 0.0021 [-0.0404, 0.0446] sex, age, birth date, deprivation index, 16 PCs —
PPM011105 PSS008843|
African Ancestry|
3,403 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Hypoglycemia — — Partial Correlation (partial-r): -0.0158 [-0.0495, 0.0179] sex, age, birth date, deprivation index, 16 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009064 — — 3,905 individuals — European Poland (NE Europe) UKB —
PSS008618 — — 6,237 individuals — European Italy (South Europe) UKB —
PSS009290 — — 18,689 individuals — European UK (+ Ireland) UKB —
PSS008172 — — 5,103 individuals — South Asian India (South Asia) UKB —
PSS008394 — — 1,092 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS008843 — — 3,403 individuals — African unspecified Nigeria (West Africa) UKB —
PSS007959 — — 1,714 individuals — East Asian China (East Asia) UKB —
PSS007740 — — 2,147 individuals — African American or Afro-Caribbean Carribean UKB —