Polygenic Score (PGS) ID: PGS002065

Predicted Trait
Reported Trait Inguinal hernia
Mapped Trait(s) Inguinal hernia (HP_0000023)
Additional Trait Information digestive
Released in PGS Catalog: Jan. 10, 2022
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Score Details

Score Construction
PGS Name portability-ldpred2_550.1
Development Method
Name LDpred2 (bigsnpr)
Parameters LDpred2-auto using HapMap3 variants
Variants
Original Genome Build GRCh37
Number of Variants 691,268
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000263
Citation (link to publication) Privé F et al. Am J Hum Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
391,124 individuals (100%)
PGS Evaluation
European: 37.5%
African: 25%
East Asian: 12.5%
Greater Middle Eastern: 12.5%
South Asian: 12.5%
8 Sample Sets

Development Samples

Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 391,124 individuals European UKB — — — UK (+ Ireland) —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM011382 PSS009329|
European Ancestry|
18,171 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Inguinal hernia — — Partial Correlation (partial-r): 0.072 [0.0575, 0.0865] sex, age, birth date, deprivation index, 16 PCs —
PPM011383 PSS009103|
European Ancestry|
3,849 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Inguinal hernia — — Partial Correlation (partial-r): 0.0516 [0.02, 0.0832] sex, age, birth date, deprivation index, 16 PCs —
PPM011384 PSS008657|
European Ancestry|
6,131 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Inguinal hernia — — Partial Correlation (partial-r): 0.0791 [0.0541, 0.1039] sex, age, birth date, deprivation index, 16 PCs —
PPM011385 PSS008431|
Greater Middle Eastern Ancestry|
1,099 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Inguinal hernia — — Partial Correlation (partial-r): 0.1064 [0.047, 0.165] sex, age, birth date, deprivation index, 16 PCs —
PPM011386 PSS008211|
South Asian Ancestry|
5,790 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Inguinal hernia — — Partial Correlation (partial-r): 0.0442 [0.0184, 0.0699] sex, age, birth date, deprivation index, 16 PCs —
PPM011387 PSS007993|
East Asian Ancestry|
1,742 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Inguinal hernia — — Partial Correlation (partial-r): 0.0374 [-0.0099, 0.0845] sex, age, birth date, deprivation index, 16 PCs —
PPM011388 PSS007776|
African Ancestry|
2,301 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Inguinal hernia — — Partial Correlation (partial-r): 0.0275 [-0.0135, 0.0685] sex, age, birth date, deprivation index, 16 PCs —
PPM011389 PSS008880|
African Ancestry|
3,668 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Inguinal hernia — — Partial Correlation (partial-r): 0.025 [-0.0074, 0.0574] sex, age, birth date, deprivation index, 16 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS008431 — — 1,099 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS009103 — — 3,849 individuals — European Poland (NE Europe) UKB —
PSS008657 — — 6,131 individuals — European Italy (South Europe) UKB —
PSS009329 — — 18,171 individuals — European UK (+ Ireland) UKB —
PSS008211 — — 5,790 individuals — South Asian India (South Asia) UKB —
PSS008880 — — 3,668 individuals — African unspecified Nigeria (West Africa) UKB —
PSS007993 — — 1,742 individuals — East Asian China (East Asia) UKB —
PSS007776 — — 2,301 individuals — African American or Afro-Caribbean Carribean UKB —