Polygenic Score (PGS) ID: PGS002080

Predicted Trait
Reported Trait Rhesus isoimmunization in pregnancy
Mapped Trait(s) Rh isoimmunization (EFO_1001159)
Additional Trait Information hematopoietic
Released in PGS Catalog: Jan. 10, 2022
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Score Details

Score Construction
PGS Name portability-ldpred2_654.2
Development Method
Name LDpred2 (bigsnpr)
Parameters LDpred2-auto using HapMap3 variants
Variants
Original Genome Build GRCh37
Number of Variants 32,414
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000263
Citation (link to publication) Privé F et al. Am J Hum Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
391,124 individuals (100%)
PGS Evaluation
European: 37.5%
African: 25%
East Asian: 12.5%
Greater Middle Eastern: 12.5%
South Asian: 12.5%
8 Sample Sets

Development Samples

Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 391,124 individuals European UKB — — — UK (+ Ireland) —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM011501 PSS009344|
European Ancestry|
10,686 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Rhesus isoimmunization in pregnancy — — Partial Correlation (partial-r): 0.0529 [0.034, 0.0718] sex, age, birth date, deprivation index, 16 PCs —
PPM011502 PSS009118|
European Ancestry|
2,539 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Rhesus isoimmunization in pregnancy — — Partial Correlation (partial-r): 0.0603 [0.0213, 0.0991] sex, age, birth date, deprivation index, 16 PCs —
PPM011503 PSS008672|
European Ancestry|
3,602 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Rhesus isoimmunization in pregnancy — — Partial Correlation (partial-r): 0.0698 [0.0371, 0.1023] sex, age, birth date, deprivation index, 16 PCs —
PPM011504 PSS008446|
Greater Middle Eastern Ancestry|
470 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Rhesus isoimmunization in pregnancy — — Partial Correlation (partial-r): 0.0432 [-0.0494, 0.135] sex, age, birth date, deprivation index, 16 PCs —
PPM011505 PSS008226|
South Asian Ancestry|
2,815 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Rhesus isoimmunization in pregnancy — — Partial Correlation (partial-r): 0.0674 [0.0305, 0.1043] sex, age, birth date, deprivation index, 16 PCs —
PPM011506 PSS008007|
East Asian Ancestry|
1,173 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Rhesus isoimmunization in pregnancy — — Partial Correlation (partial-r): 0.0096 [-0.0482, 0.0672] sex, age, birth date, deprivation index, 16 PCs —
PPM011508 PSS008895|
African Ancestry|
2,068 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Rhesus isoimmunization in pregnancy — — Partial Correlation (partial-r): 0.0234 [-0.0199, 0.0666] sex, age, birth date, deprivation index, 16 PCs —
PPM011507 PSS007791|
African Ancestry|
1,548 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Rhesus isoimmunization in pregnancy — — Partial Correlation (partial-r): -0.0192 [-0.0692, 0.031] sex, age, birth date, deprivation index, 16 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS008007 — — 1,173 individuals — East Asian China (East Asia) UKB —
PSS007791 — — 1,548 individuals — African American or Afro-Caribbean Carribean UKB —
PSS008446 — — 470 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS009118 — — 2,539 individuals — European Poland (NE Europe) UKB —
PSS008895 — — 2,068 individuals — African unspecified Nigeria (West Africa) UKB —
PSS009344 — — 10,686 individuals — European UK (+ Ireland) UKB —
PSS008672 — — 3,602 individuals — European Italy (South Europe) UKB —
PSS008226 — — 2,815 individuals — South Asian India (South Asia) UKB —