Polygenic Score (PGS) ID: PGS002081

Predicted Trait
Reported Trait Superficial cellulitis and abscess
Mapped Trait(s) cellulitis (EFO_0003035)
Additional Trait Information dermatologic
Released in PGS Catalog: Jan. 10, 2022
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Score Details

Score Construction
PGS Name portability-ldpred2_681
Development Method
Name LDpred2 (bigsnpr)
Parameters LDpred2-auto using HapMap3 variants
Variants
Original Genome Build GRCh37
Number of Variants 640,921
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000263
Citation (link to publication) Privé F et al. Am J Hum Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
391,124 individuals (100%)
PGS Evaluation
European: 37.5%
African: 25%
East Asian: 12.5%
Greater Middle Eastern: 12.5%
South Asian: 12.5%
8 Sample Sets

Development Samples

Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 391,124 individuals European UKB — — — UK (+ Ireland) —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM011509 PSS009345|
European Ancestry|
19,807 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Superficial cellulitis and abscess — — Partial Correlation (partial-r): 0.0247 [0.0108, 0.0386] sex, age, birth date, deprivation index, 16 PCs —
PPM011510 PSS009119|
European Ancestry|
4,093 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Superficial cellulitis and abscess — — Partial Correlation (partial-r): 0.0189 [-0.0118, 0.0496] sex, age, birth date, deprivation index, 16 PCs —
PPM011511 PSS008673|
European Ancestry|
6,586 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Superficial cellulitis and abscess — — Partial Correlation (partial-r): 0.009 [-0.0152, 0.0332] sex, age, birth date, deprivation index, 16 PCs —
PPM011512 PSS008447|
Greater Middle Eastern Ancestry|
1,189 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Superficial cellulitis and abscess — — Partial Correlation (partial-r): 0.021 [-0.0364, 0.0782] sex, age, birth date, deprivation index, 16 PCs —
PPM011513 PSS008227|
South Asian Ancestry|
6,213 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Superficial cellulitis and abscess — — Partial Correlation (partial-r): 0.0082 [-0.0167, 0.0331] sex, age, birth date, deprivation index, 16 PCs —
PPM011514 PSS008008|
East Asian Ancestry|
1,803 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Superficial cellulitis and abscess — — Partial Correlation (partial-r): -0.0251 [-0.0715, 0.0213] sex, age, birth date, deprivation index, 16 PCs —
PPM011516 PSS008896|
African Ancestry|
3,853 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Superficial cellulitis and abscess — — Partial Correlation (partial-r): -0.0005 [-0.0321, 0.0312] sex, age, birth date, deprivation index, 16 PCs —
PPM011515 PSS007792|
African Ancestry|
2,440 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Superficial cellulitis and abscess — — Partial Correlation (partial-r): -0.0119 [-0.0518, 0.0279] sex, age, birth date, deprivation index, 16 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS008008 — — 1,803 individuals — East Asian China (East Asia) UKB —
PSS009119 — — 4,093 individuals — European Poland (NE Europe) UKB —
PSS007792 — — 2,440 individuals — African American or Afro-Caribbean Carribean UKB —
PSS009345 — — 19,807 individuals — European UK (+ Ireland) UKB —
PSS008447 — — 1,189 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS008896 — — 3,853 individuals — African unspecified Nigeria (West Africa) UKB —
PSS008673 — — 6,586 individuals — European Italy (South Europe) UKB —
PSS008227 — — 6,213 individuals — South Asian India (South Asia) UKB —