Polygenic Score (PGS) ID: PGS002086

Predicted Trait
Reported Trait Diseases of hair and hair follicles
Mapped Trait(s) disorder of pilosebaceous unit (MONDO_0002917)
Additional Trait Information dermatologic
Released in PGS Catalog: Jan. 10, 2022
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Score Details

Score Construction
PGS Name portability-ldpred2_704
Development Method
Name LDpred2 (bigsnpr)
Parameters LDpred2-auto using HapMap3 variants
Variants
Original Genome Build GRCh37
Number of Variants 160,693
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000263
Citation (link to publication) Privé F et al. Am J Hum Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
391,124 individuals (100%)
PGS Evaluation
European: 37.5%
African: 25%
East Asian: 12.5%
Greater Middle Eastern: 12.5%
South Asian: 12.5%
8 Sample Sets

Development Samples

Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 391,124 individuals European UKB — — — UK (+ Ireland) —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM011549 PSS009124|
European Ancestry|
4,120 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Diseases of hair and hair follicles — — Partial Correlation (partial-r): 0.0931 [0.0627, 0.1234] sex, age, birth date, deprivation index, 16 PCs —
PPM011550 PSS008678|
European Ancestry|
6,645 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Diseases of hair and hair follicles — — Partial Correlation (partial-r): 0.0507 [0.0267, 0.0747] sex, age, birth date, deprivation index, 16 PCs —
PPM011551 PSS008452|
Greater Middle Eastern Ancestry|
1,195 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Diseases of hair and hair follicles — — Partial Correlation (partial-r): 0.0436 [-0.0136, 0.1005] sex, age, birth date, deprivation index, 16 PCs —
PPM011552 PSS008232|
South Asian Ancestry|
6,308 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Diseases of hair and hair follicles — — Partial Correlation (partial-r): 0.0386 [0.0139, 0.0633] sex, age, birth date, deprivation index, 16 PCs —
PPM011553 PSS008012|
East Asian Ancestry|
1,809 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Diseases of hair and hair follicles — — Partial Correlation (partial-r): -0.0205 [-0.0668, 0.0258] sex, age, birth date, deprivation index, 16 PCs —
PPM011554 PSS007797|
African Ancestry|
2,478 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Diseases of hair and hair follicles — — Partial Correlation (partial-r): -0.0452 [-0.0846, -0.0057] sex, age, birth date, deprivation index, 16 PCs —
PPM011555 PSS008901|
African Ancestry|
3,918 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Diseases of hair and hair follicles — — Partial Correlation (partial-r): 0.003 [-0.0284, 0.0344] sex, age, birth date, deprivation index, 16 PCs —
PPM011548 PSS009350|
European Ancestry|
19,926 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Diseases of hair and hair follicles — — Partial Correlation (partial-r): 0.0632 [0.0494, 0.0771] sex, age, birth date, deprivation index, 16 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009124 — — 4,120 individuals — European Poland (NE Europe) UKB —
PSS008452 — — 1,195 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS008678 — — 6,645 individuals — European Italy (South Europe) UKB —
PSS008901 — — 3,918 individuals — African unspecified Nigeria (West Africa) UKB —
PSS008232 — — 6,308 individuals — South Asian India (South Asia) UKB —
PSS009350 — — 19,926 individuals — European UK (+ Ireland) UKB —
PSS008012 — — 1,809 individuals — East Asian China (East Asia) UKB —
PSS007797 — — 2,478 individuals — African American or Afro-Caribbean Carribean UKB —