Polygenic Score (PGS) ID: PGS002100

Predicted Trait
Reported Trait Ankle spacing width
Mapped Trait(s) anthropometric measurement (EFO_0004302)
Additional Trait Information physical measures
Released in PGS Catalog: Jan. 10, 2022
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Score Details

Score Construction
PGS Name portability-ldpred2_ankle_spacing
Development Method
Name LDpred2 (bigsnpr)
Parameters LDpred2-auto using HapMap3 variants
Variants
Original Genome Build GRCh37
Number of Variants 917,925
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000263
Citation (link to publication) Privé F et al. Am J Hum Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
391,124 individuals (100%)
PGS Evaluation
European: 37.5%
African: 25%
East Asian: 12.5%
Greater Middle Eastern: 12.5%
South Asian: 12.5%
8 Sample Sets

Development Samples

Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 391,124 individuals European UKB — — — UK (+ Ireland) —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM011656 PSS009383|
European Ancestry|
11,502 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Ankle spacing width — — Partial Correlation (partial-r): 0.4158 [0.4006, 0.4309] sex, age, birth date, deprivation index, 16 PCs —
PPM011657 PSS009157|
European Ancestry|
2,149 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Ankle spacing width — — Partial Correlation (partial-r): 0.39 [0.3534, 0.4255] sex, age, birth date, deprivation index, 16 PCs —
PPM011659 PSS008485|
Greater Middle Eastern Ancestry|
507 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Ankle spacing width — — Partial Correlation (partial-r): 0.3735 [0.2944, 0.4475] sex, age, birth date, deprivation index, 16 PCs —
PPM011660 PSS008263|
South Asian Ancestry|
1,985 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Ankle spacing width — — Partial Correlation (partial-r): 0.3529 [0.3136, 0.391] sex, age, birth date, deprivation index, 16 PCs —
PPM011661 PSS008041|
East Asian Ancestry|
819 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Ankle spacing width — — Partial Correlation (partial-r): 0.3292 [0.2659, 0.3897] sex, age, birth date, deprivation index, 16 PCs —
PPM011662 PSS007827|
African Ancestry|
801 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Ankle spacing width — — Partial Correlation (partial-r): 0.2254 [0.1578, 0.291] sex, age, birth date, deprivation index, 16 PCs —
PPM011663 PSS008931|
African Ancestry|
1,421 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Ankle spacing width — — Partial Correlation (partial-r): 0.1151 [0.0632, 0.1665] sex, age, birth date, deprivation index, 16 PCs —
PPM011658 PSS008711|
European Ancestry|
3,469 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Ankle spacing width — — Partial Correlation (partial-r): 0.3974 [0.3689, 0.4251] sex, age, birth date, deprivation index, 16 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS008485 — — 507 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS009157 — — 2,149 individuals — European Poland (NE Europe) UKB —
PSS009383 — — 11,502 individuals — European UK (+ Ireland) UKB —
PSS008263 — — 1,985 individuals — South Asian India (South Asia) UKB —
PSS008041 — — 819 individuals — East Asian China (East Asia) UKB —
PSS008711 — — 3,469 individuals — European Italy (South Europe) UKB —
PSS007827 — — 801 individuals — African American or Afro-Caribbean Carribean UKB —
PSS008931 — — 1,421 individuals — African unspecified Nigeria (West Africa) UKB —