Polygenic Score (PGS) ID: PGS002149

Predicted Trait
Reported Trait Sleeplessness / insomnia
Mapped Trait(s) insomnia (EFO_0004698)
Additional Trait Information lifestyle and environment
Released in PGS Catalog: Jan. 10, 2022
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Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name portability-ldpred2_insomnia
Development Method
Name LDpred2 (bigsnpr)
Parameters LDpred2-auto using HapMap3 variants
Variants
Original Genome Build GRCh37
Number of Variants 926,585
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000263
Citation (link to publication) Privé F et al. Am J Hum Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
391,124 individuals (100%)
PGS Evaluation
European: 37.5%
African: 25%
East Asian: 12.5%
Greater Middle Eastern: 12.5%
South Asian: 12.5%
8 Sample Sets

Development Samples

Score Development/Training
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Study Identifiers
Sample Numbers
Sample Ancestry
Cohort(s)
Phenotype Definitions & Methods
Age of Study Participants
Participant Follow-up Time
Additional Ancestry Description
Additional Sample/Cohort Information
—391,124 individualsEuropeanUKB———UK (+ Ireland)—
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Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

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PGS Performance
Metric ID (PPM)
PGS Sample Set ID
(PSS)
Performance Source
Trait
PGS Effect Sizes
(per SD change)
Classification Metrics
Other Metrics
Covariates Included in the Model
PGS Performance:
Other Relevant Information
PPM012039PSS009419|
European Ancestry|
19,978 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Sleeplessness / insomnia——Partial Correlation (partial-r): 0.1411 [0.1275, 0.1547]sex, age, birth date, deprivation index, 16 PCs—
PPM012040PSS009193|
European Ancestry|
4,116 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Sleeplessness / insomnia——Partial Correlation (partial-r): 0.1208 [0.0905, 0.1508]sex, age, birth date, deprivation index, 16 PCs—
PPM012041PSS008747|
European Ancestry|
6,626 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Sleeplessness / insomnia——Partial Correlation (partial-r): 0.1253 [0.1015, 0.149]sex, age, birth date, deprivation index, 16 PCs—
PPM012042PSS008521|
Greater Middle Eastern Ancestry|
1,153 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Sleeplessness / insomnia——Partial Correlation (partial-r): 0.0852 [0.0271, 0.1427]sex, age, birth date, deprivation index, 16 PCs—
PPM012043PSS008299|
South Asian Ancestry|
6,199 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Sleeplessness / insomnia——Partial Correlation (partial-r): 0.0985 [0.0737, 0.1231]sex, age, birth date, deprivation index, 16 PCs—
PPM012044PSS008076|
East Asian Ancestry|
1,788 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Sleeplessness / insomnia——Partial Correlation (partial-r): 0.0345 [-0.0122, 0.081]sex, age, birth date, deprivation index, 16 PCs—
PPM012045PSS007863|
African Ancestry|
2,460 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Sleeplessness / insomnia——Partial Correlation (partial-r): 0.0283 [-0.0114, 0.0679]sex, age, birth date, deprivation index, 16 PCs—
PPM012046PSS008967|
African Ancestry|
3,863 individuals
PGP000263 |
Privé F et al. Am J Hum Genet (2022)
Reported Trait: Sleeplessness / insomnia——Partial Correlation (partial-r): 0.0314sex, age, birth date, deprivation index, 16 PCs—
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Evaluated Samples

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PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods
Participant Follow-up Time
Sample Numbers
Age of Study Participants
Sample Ancestry
Additional Ancestry Description
Cohort(s)
Additional Sample/Cohort Information
PSS007863——2,460 individuals—African American or Afro-CaribbeanCarribeanUKB—
PSS008076——1,788 individuals—East AsianChina (East Asia)UKB—
PSS008299——6,199 individuals—South AsianIndia (South Asia)UKB—
PSS008521——1,153 individuals—Greater Middle Eastern (Middle Eastern, North African or Persian)Iran (Middle East)UKB—
PSS008747——6,626 individuals—EuropeanItaly (South Europe)UKB—
PSS008967——3,863 individuals—African unspecifiedNigeria (West Africa)UKB—
PSS009193——4,116 individuals—EuropeanPoland (NE Europe)UKB—
PSS009419——19,978 individuals—EuropeanUK (+ Ireland)UKB—
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