Polygenic Score (PGS) ID: PGS002149

Predicted Trait
Reported Trait Sleeplessness / insomnia
Mapped Trait(s) insomnia (EFO_0004698)
Additional Trait Information lifestyle and environment
Released in PGS Catalog: Jan. 10, 2022
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Score Details

Score Construction
PGS Name portability-ldpred2_insomnia
Development Method
Name LDpred2 (bigsnpr)
Parameters LDpred2-auto using HapMap3 variants
Variants
Original Genome Build GRCh37
Number of Variants 926,585
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000263
Citation (link to publication) Privé F et al. Am J Hum Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
391,124 individuals (100%)
PGS Evaluation
European: 37.5%
African: 25%
East Asian: 12.5%
Greater Middle Eastern: 12.5%
South Asian: 12.5%
8 Sample Sets

Development Samples

Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 391,124 individuals European UKB — — — UK (+ Ireland) —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM012040 PSS009193|
European Ancestry|
4,116 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Sleeplessness / insomnia — — Partial Correlation (partial-r): 0.1208 [0.0905, 0.1508] sex, age, birth date, deprivation index, 16 PCs —
PPM012039 PSS009419|
European Ancestry|
19,978 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Sleeplessness / insomnia — — Partial Correlation (partial-r): 0.1411 [0.1275, 0.1547] sex, age, birth date, deprivation index, 16 PCs —
PPM012041 PSS008747|
European Ancestry|
6,626 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Sleeplessness / insomnia — — Partial Correlation (partial-r): 0.1253 [0.1015, 0.149] sex, age, birth date, deprivation index, 16 PCs —
PPM012042 PSS008521|
Greater Middle Eastern Ancestry|
1,153 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Sleeplessness / insomnia — — Partial Correlation (partial-r): 0.0852 [0.0271, 0.1427] sex, age, birth date, deprivation index, 16 PCs —
PPM012043 PSS008299|
South Asian Ancestry|
6,199 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Sleeplessness / insomnia — — Partial Correlation (partial-r): 0.0985 [0.0737, 0.1231] sex, age, birth date, deprivation index, 16 PCs —
PPM012044 PSS008076|
East Asian Ancestry|
1,788 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Sleeplessness / insomnia — — Partial Correlation (partial-r): 0.0345 [-0.0122, 0.081] sex, age, birth date, deprivation index, 16 PCs —
PPM012045 PSS007863|
African Ancestry|
2,460 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Sleeplessness / insomnia — — Partial Correlation (partial-r): 0.0283 [-0.0114, 0.0679] sex, age, birth date, deprivation index, 16 PCs —
PPM012046 PSS008967|
African Ancestry|
3,863 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Sleeplessness / insomnia — — Partial Correlation (partial-r): 0.0314 sex, age, birth date, deprivation index, 16 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS008967 — — 3,863 individuals — African unspecified Nigeria (West Africa) UKB —
PSS009193 — — 4,116 individuals — European Poland (NE Europe) UKB —
PSS008521 — — 1,153 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS008747 — — 6,626 individuals — European Italy (South Europe) UKB —
PSS008299 — — 6,199 individuals — South Asian India (South Asia) UKB —
PSS009419 — — 19,978 individuals — European UK (+ Ireland) UKB —
PSS008076 — — 1,788 individuals — East Asian China (East Asia) UKB —
PSS007863 — — 2,460 individuals — African American or Afro-Caribbean Carribean UKB —