Polygenic Score (PGS) ID: PGS002154

Predicted Trait
Reported Trait General happiness
Mapped Trait(s) wellbeing measurement (EFO_0007869)
Additional Trait Information lifestyle and environment
Released in PGS Catalog: Jan. 10, 2022
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Score Details

Score Construction
PGS Name portability-ldpred2_less_happy
Development Method
Name LDpred2 (bigsnpr)
Parameters LDpred2-auto using HapMap3 variants
Variants
Original Genome Build GRCh37
Number of Variants 806,011
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000263
Citation (link to publication) Privé F et al. Am J Hum Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
391,124 individuals (100%)
PGS Evaluation
European: 37.5%
African: 25%
East Asian: 12.5%
Greater Middle Eastern: 12.5%
South Asian: 12.5%
8 Sample Sets

Development Samples

Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 391,124 individuals European UKB — — — UK (+ Ireland) —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM012079 PSS009422|
European Ancestry|
6,429 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: General happiness — — Partial Correlation (partial-r): 0.105 [0.0807, 0.1291] sex, age, birth date, deprivation index, 16 PCs —
PPM012080 PSS009196|
European Ancestry|
1,241 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: General happiness — — Partial Correlation (partial-r): 0.0947 [0.0389, 0.1501] sex, age, birth date, deprivation index, 16 PCs —
PPM012081 PSS008750|
European Ancestry|
2,243 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: General happiness — — Partial Correlation (partial-r): 0.0889 [0.0475, 0.1299] sex, age, birth date, deprivation index, 16 PCs —
PPM012082 PSS008524|
Greater Middle Eastern Ancestry|
199 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: General happiness — — Partial Correlation (partial-r): 0.0539 [-0.0935, 0.199] sex, age, birth date, deprivation index, 16 PCs —
PPM012083 PSS008302|
South Asian Ancestry|
809 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: General happiness — — Partial Correlation (partial-r): 0.0216 [-0.0483, 0.0912] sex, age, birth date, deprivation index, 16 PCs —
PPM012084 PSS008079|
East Asian Ancestry|
424 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: General happiness — — Partial Correlation (partial-r): 0.0257 [-0.0721, 0.1229] sex, age, birth date, deprivation index, 16 PCs —
PPM012085 PSS007866|
African Ancestry|
368 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: General happiness — — Partial Correlation (partial-r): 0.0163 [-0.0889, 0.1213] sex, age, birth date, deprivation index, 16 PCs —
PPM012086 PSS008970|
African Ancestry|
503 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: General happiness — — Partial Correlation (partial-r): 0.0196 [-0.0697, 0.1086] sex, age, birth date, deprivation index, 16 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS008970 — — 503 individuals — African unspecified Nigeria (West Africa) UKB —
PSS009196 — — 1,241 individuals — European Poland (NE Europe) UKB —
PSS008524 — — 199 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS009422 — — 6,429 individuals — European UK (+ Ireland) UKB —
PSS008750 — — 2,243 individuals — European Italy (South Europe) UKB —
PSS008302 — — 809 individuals — South Asian India (South Asia) UKB —
PSS008079 — — 424 individuals — East Asian China (East Asia) UKB —
PSS007866 — — 368 individuals — African American or Afro-Caribbean Carribean UKB —