Polygenic Score (PGS) ID: PGS002166

Predicted Trait
Reported Trait QRS duration
Mapped Trait(s) QRS duration (EFO_0005055)
Additional Trait Information physical measures
Released in PGS Catalog: Jan. 10, 2022
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Score Details

Score Construction
PGS Name portability-ldpred2_log_ECG_QRS_duration
Development Method
Name LDpred2 (bigsnpr)
Parameters LDpred2-auto using HapMap3 variants
Variants
Original Genome Build GRCh37
Number of Variants 471,172
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000263
Citation (link to publication) Privé F et al. Am J Hum Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
391,124 individuals (100%)
PGS Evaluation
European: 37.5%
African: 25%
East Asian: 12.5%
Greater Middle Eastern: 12.5%
South Asian: 12.5%
8 Sample Sets

Development Samples

Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 391,124 individuals European UKB — — — UK (+ Ireland) —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM012175 PSS009431|
European Ancestry|
1,702 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: QRS duration — — Partial Correlation (partial-r): 0.2257 [0.1798, 0.2706] sex, age, birth date, deprivation index, 16 PCs —
PPM012176 PSS009205|
European Ancestry|
329 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: QRS duration — — Partial Correlation (partial-r): 0.1797 [0.0695, 0.2855] sex, age, birth date, deprivation index, 16 PCs —
PPM012177 PSS008759|
European Ancestry|
487 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: QRS duration — — Partial Correlation (partial-r): 0.2307 [0.143, 0.3149] sex, age, birth date, deprivation index, 16 PCs —
PPM012178 PSS008533|
Greater Middle Eastern Ancestry|
50 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: QRS duration — — Partial Correlation (partial-r): 0.2134 [-0.1591, 0.5327] sex, age, birth date, deprivation index, 16 PCs —
PPM012179 PSS008311|
South Asian Ancestry|
305 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: QRS duration — — Partial Correlation (partial-r): 0.2354 [0.1226, 0.3422] sex, age, birth date, deprivation index, 16 PCs —
PPM012180 PSS008088|
East Asian Ancestry|
137 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: QRS duration — — Partial Correlation (partial-r): 0.0367 [-0.1458, 0.2168] sex, age, birth date, deprivation index, 16 PCs —
PPM012181 PSS007875|
African Ancestry|
77 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: QRS duration — — Partial Correlation (partial-r): 0.1029 [-0.162, 0.354] sex, age, birth date, deprivation index, 16 PCs —
PPM012182 PSS008979|
African Ancestry|
140 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: QRS duration — — Partial Correlation (partial-r): 0.0257 [-0.1542, 0.204] sex, age, birth date, deprivation index, 16 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS008979 — — 140 individuals — African unspecified Nigeria (West Africa) UKB —
PSS009205 — — 329 individuals — European Poland (NE Europe) UKB —
PSS008533 — — 50 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS009431 — — 1,702 individuals — European UK (+ Ireland) UKB —
PSS008759 — — 487 individuals — European Italy (South Europe) UKB —
PSS008311 — — 305 individuals — South Asian India (South Asia) UKB —
PSS008088 — — 137 individuals — East Asian China (East Asia) UKB —
PSS007875 — — 77 individuals — African American or Afro-Caribbean Carribean UKB —