Polygenic Score (PGS) ID: PGS002178

Predicted Trait
Reported Trait IGF-1
Mapped Trait(s) IGF-1 measurement (EFO_0004627)
Additional Trait Information biological measures
Released in PGS Catalog: Jan. 10, 2022
Download Score FTP directory
Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name portability-ldpred2_log_IGF1
Development Method
Name LDpred2 (bigsnpr)
Parameters LDpred2-auto using HapMap3 variants
Variants
Original Genome Build GRCh37
Number of Variants 817,740
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000263
Citation (link to publication) Privé F et al. Am J Hum Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
391,124 individuals (100%)
PGS Evaluation
European: 37.5%
African: 25%
East Asian: 12.5%
Greater Middle Eastern: 12.5%
South Asian: 12.5%
8 Sample Sets

Development Samples

Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 391,124 individuals European UKB — — — UK (+ Ireland) —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM012271 PSS009435|
European Ancestry|
18,901 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: IGF-1 — — Partial Correlation (partial-r): 0.3913 [0.3791, 0.4033] sex, age, birth date, deprivation index, 16 PCs —
PPM012272 PSS009209|
European Ancestry|
3,935 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: IGF-1 — — Partial Correlation (partial-r): 0.3623 [0.3347, 0.3892] sex, age, birth date, deprivation index, 16 PCs —
PPM012273 PSS008763|
European Ancestry|
6,290 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: IGF-1 — — Partial Correlation (partial-r): 0.3614 [0.3397, 0.3827] sex, age, birth date, deprivation index, 16 PCs —
PPM012275 PSS008315|
South Asian Ancestry|
5,961 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: IGF-1 — — Partial Correlation (partial-r): 0.3299 [0.3071, 0.3524] sex, age, birth date, deprivation index, 16 PCs —
PPM012276 PSS008092|
East Asian Ancestry|
1,710 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: IGF-1 — — Partial Correlation (partial-r): 0.2809 [0.2364, 0.3242] sex, age, birth date, deprivation index, 16 PCs —
PPM012277 PSS007879|
African Ancestry|
2,328 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: IGF-1 — — Partial Correlation (partial-r): 0.1863 [0.1466, 0.2254] sex, age, birth date, deprivation index, 16 PCs —
PPM012278 PSS008983|
African Ancestry|
3,637 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: IGF-1 — — Partial Correlation (partial-r): 0.2085 [0.1771, 0.2395] sex, age, birth date, deprivation index, 16 PCs —
PPM012274 PSS008537|
Greater Middle Eastern Ancestry|
1,118 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: IGF-1 — — Partial Correlation (partial-r): 0.3575 [0.3048, 0.408] sex, age, birth date, deprivation index, 16 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS007879 — — 2,328 individuals — African American or Afro-Caribbean Carribean UKB —
PSS008983 — — 3,637 individuals — African unspecified Nigeria (West Africa) UKB —
PSS009209 — — 3,935 individuals — European Poland (NE Europe) UKB —
PSS008537 — — 1,118 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS008763 — — 6,290 individuals — European Italy (South Europe) UKB —
PSS008092 — — 1,710 individuals — East Asian China (East Asia) UKB —
PSS008315 — — 5,961 individuals — South Asian India (South Asia) UKB —
PSS009435 — — 18,901 individuals — European UK (+ Ireland) UKB —