Polygenic Score (PGS) ID: PGS002196

Predicted Trait
Reported Trait Sleep duration
Mapped Trait(s) sleep duration (EFO_0005271)
Additional Trait Information lifestyle and environment
Released in PGS Catalog: Jan. 10, 2022
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Score Details

Score Construction
PGS Name portability-ldpred2_log_sleep
Development Method
Name LDpred2 (bigsnpr)
Parameters LDpred2-auto using HapMap3 variants
Variants
Original Genome Build GRCh37
Number of Variants 927,619
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000263
Citation (link to publication) Privé F et al. Am J Hum Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
391,124 individuals (100%)
PGS Evaluation
European: 37.5%
African: 25%
East Asian: 12.5%
Greater Middle Eastern: 12.5%
South Asian: 12.5%
8 Sample Sets

Development Samples

Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 391,124 individuals European UKB — — — UK (+ Ireland) —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM012415 PSS009466|
European Ancestry|
19,860 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Sleep duration — — Partial Correlation (partial-r): 0.1451 [0.1315, 0.1587] sex, age, birth date, deprivation index, 16 PCs —
PPM012416 PSS009240|
European Ancestry|
4,085 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Sleep duration — — Partial Correlation (partial-r): 0.1583 [0.1282, 0.1881] sex, age, birth date, deprivation index, 16 PCs —
PPM012417 PSS008794|
European Ancestry|
6,577 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Sleep duration — — Partial Correlation (partial-r): 0.1459 [0.1221, 0.1695] sex, age, birth date, deprivation index, 16 PCs —
PPM012418 PSS008568|
Greater Middle Eastern Ancestry|
1,136 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Sleep duration — — Partial Correlation (partial-r): 0.1258 [0.0676, 0.1831] sex, age, birth date, deprivation index, 16 PCs —
PPM012419 PSS008346|
South Asian Ancestry|
6,129 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Sleep duration — — Partial Correlation (partial-r): 0.0788 [0.0539, 0.1037] sex, age, birth date, deprivation index, 16 PCs —
PPM012420 PSS008123|
East Asian Ancestry|
1,773 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Sleep duration — — Partial Correlation (partial-r): 0.0978 [0.0512, 0.1439] sex, age, birth date, deprivation index, 16 PCs —
PPM012421 PSS007910|
African Ancestry|
2,358 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Sleep duration — — Partial Correlation (partial-r): 0.0851 [0.0447, 0.1252] sex, age, birth date, deprivation index, 16 PCs —
PPM012422 PSS009014|
African Ancestry|
3,721 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Sleep duration — — Partial Correlation (partial-r): 0.0331 sex, age, birth date, deprivation index, 16 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS007910 — — 2,358 individuals — African American or Afro-Caribbean Carribean UKB —
PSS009014 — — 3,721 individuals — African unspecified Nigeria (West Africa) UKB —
PSS008123 — — 1,773 individuals — East Asian China (East Asia) UKB —
PSS008568 — — 1,136 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS009240 — — 4,085 individuals — European Poland (NE Europe) UKB —
PSS008794 — — 6,577 individuals — European Italy (South Europe) UKB —
PSS008346 — — 6,129 individuals — South Asian India (South Asia) UKB —
PSS009466 — — 19,860 individuals — European UK (+ Ireland) UKB —