Polygenic Score (PGS) ID: PGS002197

Predicted Trait
Reported Trait Triglycerides
Mapped Trait(s) triglyceride measurement (EFO_0004530)
Additional Trait Information biological measures
Released in PGS Catalog: Jan. 10, 2022
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Score Details

Score Construction
PGS Name portability-ldpred2_log_triglycerides
Development Method
Name LDpred2 (bigsnpr)
Parameters LDpred2-auto using HapMap3 variants
Variants
Original Genome Build GRCh37
Number of Variants 731,035
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000263
Citation (link to publication) Privé F et al. Am J Hum Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
391,124 individuals (100%)
PGS Evaluation
European: 40%
African: 30%
East Asian: 10%
Greater Middle Eastern: 10%
South Asian: 10%
10 Sample Sets

Development Samples

Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 391,124 individuals European UKB — — — UK (+ Ireland) —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM012423 PSS009467|
European Ancestry|
18,986 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Triglycerides — — Partial Correlation (partial-r): 0.3655 [0.3531, 0.3778] sex, age, birth date, deprivation index, 16 PCs —
PPM012424 PSS009241|
European Ancestry|
3,948 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Triglycerides — — Partial Correlation (partial-r): 0.3494 [0.3216, 0.3766] sex, age, birth date, deprivation index, 16 PCs —
PPM012425 PSS008795|
European Ancestry|
6,319 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Triglycerides — — Partial Correlation (partial-r): 0.3526 [0.3308, 0.374] sex, age, birth date, deprivation index, 16 PCs —
PPM012426 PSS008569|
Greater Middle Eastern Ancestry|
1,122 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Triglycerides — — Partial Correlation (partial-r): 0.3093 [0.2549, 0.3617] sex, age, birth date, deprivation index, 16 PCs —
PPM012427 PSS008347|
South Asian Ancestry|
5,996 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Triglycerides — — Partial Correlation (partial-r): 0.3545 [0.3322, 0.3765] sex, age, birth date, deprivation index, 16 PCs —
PPM012428 PSS008124|
East Asian Ancestry|
1,716 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Triglycerides — — Partial Correlation (partial-r): 0.256 [0.211, 0.3] sex, age, birth date, deprivation index, 16 PCs —
PPM012429 PSS007911|
African Ancestry|
2,345 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Triglycerides — — Partial Correlation (partial-r): 0.1776 [0.138, 0.2167] sex, age, birth date, deprivation index, 16 PCs —
PPM012430 PSS009015|
African Ancestry|
3,653 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Triglycerides — — Partial Correlation (partial-r): 0.1521 [0.1202, 0.1837] sex, age, birth date, deprivation index, 16 PCs —
PPM020896 PSS011441|
African Ancestry|
504 individuals
 PGP000599 |
Guarischi-Sousa R et al. Circ Genom Precis Med (2023)
|Ext.		 Reported Trait: Raised coronary lesion OR: 1.03 [0.84, 1.26] — — — —
PPM020888 PSS011442|
European Ancestry|
564 individuals
 PGP000599 |
Guarischi-Sousa R et al. Circ Genom Precis Med (2023)
|Ext.		 Reported Trait: Raised coronary lesion OR: 1.04 [0.86, 1.25] — — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011441 — —
[
  • 165 cases
  • , 339 controls
]
,
82.0 % Male samples
 Mean = 27.5 years African unspecified — PDAY —
PSS007911 — — 2,345 individuals — African American or Afro-Caribbean Carribean UKB —
PSS011442 — —
[
  • 181 cases
  • , 383 controls
]
,
77.0 % Male samples
 Mean = 26.7 years European — PDAY —
PSS009015 — — 3,653 individuals — African unspecified Nigeria (West Africa) UKB —
PSS008569 — — 1,122 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS009241 — — 3,948 individuals — European Poland (NE Europe) UKB —
PSS008795 — — 6,319 individuals — European Italy (South Europe) UKB —
PSS008124 — — 1,716 individuals — East Asian China (East Asia) UKB —
PSS008347 — — 5,996 individuals — South Asian India (South Asia) UKB —
PSS009467 — — 18,986 individuals — European UK (+ Ireland) UKB —