Polygenic Score (PGS) ID: PGS002212

Predicted Trait
Reported Trait Daytime dozing / sleeping (narcolepsy)
Mapped Trait(s) narcolepsy (MONDO_0021107)
Additional Trait Information physical measures
Released in PGS Catalog: Jan. 10, 2022
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Score Details

Score Construction
PGS Name portability-ldpred2_narcolepsy
Development Method
Name LDpred2 (bigsnpr)
Parameters LDpred2-auto using HapMap3 variants
Variants
Original Genome Build GRCh37
Number of Variants 893,802
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000263
Citation (link to publication) Privé F et al. Am J Hum Genet (2022)
Ancestry Distribution
Score Development/Training
European: 100%
391,124 individuals (100%)
PGS Evaluation
European: 37.5%
African: 25%
East Asian: 12.5%
Greater Middle Eastern: 12.5%
South Asian: 12.5%
8 Sample Sets

Development Samples

Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
— 391,124 individuals European UKB — — — UK (+ Ireland) —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM012543 PSS009478|
European Ancestry|
19,922 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Daytime dozing / sleeping (narcolepsy) — — Partial Correlation (partial-r): 0.1104 [0.0966, 0.1241] sex, age, birth date, deprivation index, 16 PCs —
PPM012544 PSS009252|
European Ancestry|
4,057 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Daytime dozing / sleeping (narcolepsy) — — Partial Correlation (partial-r): 0.0922 [0.0616, 0.1227] sex, age, birth date, deprivation index, 16 PCs —
PPM012545 PSS008806|
European Ancestry|
6,571 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Daytime dozing / sleeping (narcolepsy) — — Partial Correlation (partial-r): 0.0802 [0.0561, 0.1042] sex, age, birth date, deprivation index, 16 PCs —
PPM012546 PSS008580|
Greater Middle Eastern Ancestry|
1,078 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Daytime dozing / sleeping (narcolepsy) — — Partial Correlation (partial-r): 0.0377 [-0.0227, 0.0977] sex, age, birth date, deprivation index, 16 PCs —
PPM012547 PSS008358|
South Asian Ancestry|
6,001 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Daytime dozing / sleeping (narcolepsy) — — Partial Correlation (partial-r): 0.0784 [0.0531, 0.1035] sex, age, birth date, deprivation index, 16 PCs —
PPM012548 PSS008135|
East Asian Ancestry|
1,752 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Daytime dozing / sleeping (narcolepsy) — — Partial Correlation (partial-r): 0.0407 [-0.0064, 0.0876] sex, age, birth date, deprivation index, 16 PCs —
PPM012549 PSS007922|
African Ancestry|
2,395 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Daytime dozing / sleeping (narcolepsy) — — Partial Correlation (partial-r): 0.05 [0.0098, 0.0901] sex, age, birth date, deprivation index, 16 PCs —
PPM012550 PSS009026|
African Ancestry|
3,750 individuals
 PGP000263 |
Privé F et al. Am J Hum Genet (2022)
 Reported Trait: Daytime dozing / sleeping (narcolepsy) — — Partial Correlation (partial-r): 0.0511 [0.019, 0.0831] sex, age, birth date, deprivation index, 16 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009252 — — 4,057 individuals — European Poland (NE Europe) UKB —
PSS008580 — — 1,078 individuals — Greater Middle Eastern (Middle Eastern, North African or Persian) Iran (Middle East) UKB —
PSS008358 — — 6,001 individuals — South Asian India (South Asia) UKB —
PSS009478 — — 19,922 individuals — European UK (+ Ireland) UKB —
PSS008806 — — 6,571 individuals — European Italy (South Europe) UKB —
PSS008135 — — 1,752 individuals — East Asian China (East Asia) UKB —
PSS007922 — — 2,395 individuals — African American or Afro-Caribbean Carribean UKB —
PSS009026 — — 3,750 individuals — African unspecified Nigeria (West Africa) UKB —