Polygenic Score (PGS) ID: PGS002273

Predicted Trait
Reported Trait COVID-19 infection
Mapped Trait(s) COVID-19 (MONDO_0100096)
Released in PGS Catalog: April 1, 2022
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Score Details

Score Construction
PGS Name GRS12_COVID
Development Method
Name Genome-wide significant variants
Parameters p < 5E-08
Variants
Original Genome Build GRCh38
Number of Variants 12
Effect Weight Type log(OR)
PGS Source
PGS Catalog Publication (PGP) ID PGP000302
Citation (link to publication) Horowitz JE et al. Nat Genet (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 82.3%
Hispanic or Latin American: 12.2%
African: 3.7%
South Asian: 1.1%
East Asian: 0.7%
127,704 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST90013412
Europe PMC: 33307546
 1,092 individuals African unspecified NR
GWAS Catalog: GCST90013413
Europe PMC: 33307546
 894 individuals East Asian NR
GWAS Catalog: GCST90013414
Europe PMC: 33307546
 10,056 individuals European NR
GWAS Catalog: GCST90013415
Europe PMC: 33307546
 1,422 individuals South Asian NR
GWAS Catalog: GCST90027245
Europe PMC: 33888907
 94,985 individuals European NR
GWAS Catalog: GCST90027245
Europe PMC: 33888907
 15,639 individuals Hispanic or Latin American NR
GWAS Catalog: GCST90027245
Europe PMC: 33888907
 3,616 individuals African American or Afro-Caribbean, African unspecified NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM012931 PSS009624|
European Ancestry|
44,958 individuals
 PGP000302 |
Horowitz JE et al. Nat Genet (2022)
 Reported Trait: Risk of hospitalization (COVID-19) — — OR (top 10% vs rest of population): 1.38 [1.26, 1.52] Age, sex, age-by-sex interaction and ten ancestry-informative PCs —
PPM012932 PSS009624|
European Ancestry|
44,958 individuals
 PGP000302 |
Horowitz JE et al. Nat Genet (2022)
 Reported Trait: Risk of severe disease (COVID-19) — — OR (top 10% vs rest of population): 1.64 [1.43, 1.9] Age, sex, age-by-sex interaction and ten ancestry-informative PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009624 COVID-19 positive, that is, those with a positive qPCR orserology test for SARS-CoV-2 or with a COVID-19-related ICD-10 code (U07), hospitalization or death — 44,958 individuals — European — AncestryDNA, MyCode, UKB Meta-analysis