Polygenic Score (PGS) ID: PGS002280

Predicted Trait
Reported Trait Alzheimer's disease
Mapped Trait(s) Alzheimer disease (MONDO_0004975)
Released in PGS Catalog: April 13, 2022
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Score Details

Score Construction
PGS Name GRS83_AD
Development Method
Name Genome-wide significant variants
Parameters excluding APOE
Variants
Original Genome Build GRCh38
Number of Variants 83
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000309
Citation (link to publication) Bellenguez C et al. Nat Genet (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
487,511 individuals (100%)
PGS Evaluation
European: 100%
5 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
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Study Identifiers
Sample Numbers
Sample Ancestry
Cohort(s)
GWAS Catalog: GCST90027158
[
  • 85,934 cases
  • , 401,577 controls
]
EuropeanNR
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Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

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PGS Performance
Metric ID (PPM)
PGS Sample Set ID
(PSS)
Performance Source
Trait
PGS Effect Sizes
(per SD change)
Classification Metrics
Other Metrics
Covariates Included in the Model
PGS Performance:
Other Relevant Information
PPM012966PSS009635|
European Ancestry|
17,545 individuals
PGP000309 |
Bellenguez C et al. Nat Genet (2022)
Reported Trait: Conversion to Alzheimer diseaseHR: 1.076 [1.064, 1.088]Hazard Ratio (HR; highest vs. lowest decile): 1.93 [1.75, 2.13]Age, sex, number of APOE-ε4 and APOE-ε2 alleles and genetic principal componentsFixed-effect meta-analysis
PPM012967PSS009634|
European Ancestry|
4,114 individuals
PGP000309 |
Bellenguez C et al. Nat Genet (2022)
Reported Trait: Conversion to Alzheimer disease (in mild cognitive impairment)HR: 1.056 [1.04, 1.072]Hazard Ratio (HR; highest vs. lowest decile): 1.63 [1.42, 1.87]Age, sex, number of APOE-ε4 and APOE-ε2 alleles and genetic principal componentsFixed-effect meta-analysis
PPM012968PSS009635|
European Ancestry|
17,545 individuals
PGP000309 |
Bellenguez C et al. Nat Genet (2022)
Reported Trait: Conversion to Alzheimer disease within 5 yearsNRI (net reclassification improvement): 0.248 [0.159, 0.336]
Delta C-index: 0.002 [0.0004, 0.004]
Age, sex, number of APOE-ε4 and APOE-ε2 alleles and genetic principal componentsFixed-effect meta-analysis
PPM012969PSS009635|
European Ancestry|
17,545 individuals
PGP000309 |
Bellenguez C et al. Nat Genet (2022)
Reported Trait: Conversion to Alzheimer disease within 3 years (in mild cognitive impairment)NRI (net reclassification improvement): 0.232 [0.14, 0.325]
Delta C-index: 0.007 [0.001, 0.012]
Age, sex, number of APOE-ε4 and APOE-ε2 alleles and genetic principal componentsFixed-effect meta-analysis
PPM022295PSS011907|
European Ancestry|
3,285 individuals
PGP000698 |
Gorijala P et al. Alzheimers Dement (2023)
|Ext.
Reported Trait: Sporadic early-onset Alzheimer's diseaseOdds ratio (OR, high vs low PGS tertile): 2.56 [1.95, 3.39]Sex
PPM022296PSS011906|
European Ancestry|
4,303 individuals
PGP000698 |
Gorijala P et al. Alzheimers Dement (2023)
|Ext.
Reported Trait: Familial late-onset Alzheimer's diseaseOdds ratio (OR, high vs low PGS tertile): 2.31 [1.97, 2.72]Sex
PPM022297PSS011908|
European Ancestry|
5,149 individuals
PGP000698 |
Gorijala P et al. Alzheimers Dement (2023)
|Ext.
Reported Trait: Sporadic late-onset Alzheimer's diseaseOdds ratio (OR, high vs low PGS tertile): 1.67 [1.46, 1.91]Sex
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Evaluated Samples

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PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods
Participant Follow-up Time
Sample Numbers
Age of Study Participants
Sample Ancestry
Additional Ancestry Description
Cohort(s)
Additional Sample/Cohort Information
PSS0096344,114 individualsEuropeanADCDCN, FACE, HAN, UAN, UHA, AMC, ZIM
PSS00963517,545 individualsEuropean3C, FHS, MAS, RSAgeCoDe, VITA
PSS011906
[
  • 1,413 cases
  • , 2,890 controls
]
EuropeanNIA-LOAD
PSS011907
[
  • 395 cases
  • , 2,890 controls
]
EuropeanADNI, Knight-ADRC
PSS011908
[
  • 2,259 cases
  • , 2,890 controls
]
EuropeanADNI, Knight-ADRC
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