Polygenic Score (PGS) ID: PGS002321

Predicted Trait
Reported Trait Diabetes (any type)
Mapped Trait(s) diabetes mellitus (EFO_0000400)
Released in PGS Catalog: June 9, 2022
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Score Details

Score Construction
PGS Name disease_DIABETES_ANY_DIAGNOSED.BOLT-LMM
Development Method
Name BOLT-LMM
Parameters NR
Variants
Original Genome Build GRCh37
Number of Variants 1,109,311
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000332
Citation (link to publication) Weissbrod O et al. Nat Genet (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
336,759 individuals (100%)
PGS Evaluation
African: 25%
East Asian: 25%
European: 25%
South Asian: 25%
4 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
— 336,759 individuals European UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM013086 PSS009727|
African Ancestry|
6,430 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Diabetes (any type) — — Incremental R2 (full model vs. covariates alone): 0.005 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013135 PSS009728|
East Asian Ancestry|
898 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Diabetes (any type) — — Incremental R2 (full model vs. covariates alone): 0.006 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013184 PSS009729|
European Ancestry|
43,355 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Diabetes (any type) — — Incremental R2 (full model vs. covariates alone): 0.0159 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013233 PSS009730|
South Asian Ancestry|
7,926 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Diabetes (any type) — — Incremental R2 (full model vs. covariates alone): 0.028 age, sex, age*sex, assessment center, genotyping array, 10 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009727 — — 6,430 individuals — African unspecified — UKB —
PSS009728 — — 898 individuals — East Asian — UKB —
PSS009729 — — 43,355 individuals — European Non-British European UKB —
PSS009730 — — 7,926 individuals — South Asian — UKB —