Polygenic Score (PGS) ID: PGS002375

Predicted Trait
Reported Trait Smoking status
Mapped Trait(s) smoking status measurement (EFO_0006527)
Released in PGS Catalog: June 9, 2022
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Score Details

Score Construction
PGS Name cov_SMOKING_STATUS.BOLT-LMM-BBJ
Development Method
Name BOLT-LMM-BBJ
Parameters NR
Variants
Original Genome Build GRCh37
Number of Variants 920,934
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000332
Citation (link to publication) Weissbrod O et al. Nat Genet (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
East Asian: 100%
124,000 individuals (100%)
PGS Evaluation
African: 25%
East Asian: 25%
European: 25%
South Asian: 25%
4 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
— 124,000 individuals East Asian BBJ

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM013287 PSS009835|
African Ancestry|
6,455 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Smoking status — — Incremental R2 (full model vs. covariates alone): 0.0003 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013310 PSS009836|
East Asian Ancestry|
920 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Smoking status — — Incremental R2 (full model vs. covariates alone): 0.0014 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013333 PSS009837|
European Ancestry|
43,338 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Smoking status — — Incremental R2 (full model vs. covariates alone): 0.0003 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013356 PSS009838|
South Asian Ancestry|
8,007 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Smoking status — — Incremental R2 (full model vs. covariates alone): 0.0001 age, sex, age*sex, assessment center, genotyping array, 10 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009836 — — 920 individuals — East Asian — UKB —
PSS009837 — — 43,338 individuals — European Non-British European UKB —
PSS009838 — — 8,007 individuals — South Asian — UKB —
PSS009835 — — 6,455 individuals — African unspecified — UKB —