Polygenic Score (PGS) ID: PGS002378

Predicted Trait
Reported Trait Triglycerides
Mapped Trait(s) triglyceride measurement (EFO_0004530)
Released in PGS Catalog: June 9, 2022
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Score Details

Score Construction
PGS Name biochemistry_Triglycerides.BOLT-LMM-BBJ
Development Method
Name BOLT-LMM-BBJ
Parameters NR
Variants
Original Genome Build GRCh37
Number of Variants 920,927
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000332
Citation (link to publication) Weissbrod O et al. Nat Genet (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
East Asian: 100%
124,000 individuals (100%)
PGS Evaluation
African: 25%
East Asian: 25%
European: 25%
South Asian: 25%
4 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
— 124,000 individuals East Asian BBJ

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM013290 PSS009855|
African Ancestry|
6,066 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Triglycerides — — Incremental R2 (full model vs. covariates alone): 0.0037 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013313 PSS009856|
East Asian Ancestry|
868 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Triglycerides — — Incremental R2 (full model vs. covariates alone): 0.0522 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013336 PSS009857|
European Ancestry|
40,890 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Triglycerides — — Incremental R2 (full model vs. covariates alone): 0.009 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013359 PSS009858|
South Asian Ancestry|
7,553 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Triglycerides — — Incremental R2 (full model vs. covariates alone): 0.0212 age, sex, age*sex, assessment center, genotyping array, 10 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009855 — — 6,066 individuals — African unspecified — UKB —
PSS009856 — — 868 individuals — East Asian — UKB —
PSS009857 — — 40,890 individuals — European Non-British European UKB —
PSS009858 — — 7,553 individuals — South Asian — UKB —