| Predicted Trait | |
| Reported Trait | Chronotype (morning person) |
| Mapped Trait(s) | chronotype measurement (EFO_0008328) |
| Score Construction | |
| PGS Name | other_MORNINGPERSON.P+T.0.0001 |
| Development Method | |
| Name | Pruning and Thresholding (P+T) |
| Parameters | p < 0.0001 |
| Variants | |
| Original Genome Build | GRCh37 |
| Number of Variants | 3,625 |
| Effect Weight Type | beta |
| PGS Source | |
| PGS Catalog Publication (PGP) ID | PGP000332 |
| Citation (link to publication) | Weissbrod O et al. Nat Genet (2022) |
| Ancestry Distribution | |
| Source of Variant Associations (GWAS) | European: 100% 301,397 individuals (100%) |
| PGS Evaluation | African: 25% East Asian: 25% European: 25% South Asian: 25% 4 Sample Sets |
Study Identifiers
|
Sample Numbers
|
Sample Ancestry
|
Cohort(s)
|
|---|---|---|---|
| — | 301,397 individuals | European | UKB |
PGS Performance Metric ID (PPM) |
PGS Sample Set ID (PSS) |
Performance Source
|
Trait
|
PGS Effect Sizes (per SD change) |
Classification Metrics
|
Other Metrics
|
Covariates Included in the Model
|
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|
| PPM013371 | PSS009715| African Ancestry| 5,524 individuals | PGP000332 | Weissbrod O et al. Nat Genet (2022) | Reported Trait: Chronotype (morning person) | — | — | Incremental R2 (full model vs. covariates alone): 0.0009 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | — |
| PPM013420 | PSS009716| East Asian Ancestry| 827 individuals | PGP000332 | Weissbrod O et al. Nat Genet (2022) | Reported Trait: Chronotype (morning person) | — | — | Incremental R2 (full model vs. covariates alone): 0.0073 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | — |
| PPM013469 | PSS009717| European Ancestry| 39,178 individuals | PGP000332 | Weissbrod O et al. Nat Genet (2022) | Reported Trait: Chronotype (morning person) | — | — | Incremental R2 (full model vs. covariates alone): 0.0108 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | — |
| PPM013518 | PSS009718| South Asian Ancestry| 6,975 individuals | PGP000332 | Weissbrod O et al. Nat Genet (2022) | Reported Trait: Chronotype (morning person) | — | — | Incremental R2 (full model vs. covariates alone): 0.0048 | age, sex, age*sex, assessment center, genotyping array, 10 PCs | — |
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods
|
Participant Follow-up Time
|
Sample Numbers
|
Age of Study Participants
|
Sample Ancestry
|
Additional Ancestry Description
|
Cohort(s)
|
Additional Sample/Cohort Information
|
|---|---|---|---|---|---|---|---|---|
| PSS009715 | — | — | 5,524 individuals | — | African unspecified | — | UKB | — |
| PSS009716 | — | — | 827 individuals | — | East Asian | — | UKB | — |
| PSS009717 | — | — | 39,178 individuals | — | European | Non-British European | UKB | — |
| PSS009718 | — | — | 6,975 individuals | — | South Asian | — | UKB | — |