Polygenic Score (PGS) ID: PGS002495

Predicted Trait
Reported Trait Eosinophil count
Mapped Trait(s) eosinophil count (EFO_0004842)
Released in PGS Catalog: June 9, 2022
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Score Details

Score Construction
PGS Name blood_EOSINOPHIL_COUNT.P+T.0.01
Development Method
Name Pruning and Thresholding (P+T)
Parameters p < 0.01
Variants
Original Genome Build GRCh37
Number of Variants 135,927
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000332
Citation (link to publication) Weissbrod O et al. Nat Genet (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
323,358 individuals (100%)
PGS Evaluation
African: 25%
East Asian: 25%
European: 25%
South Asian: 25%
4 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
— 323,358 individuals European UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM013770 PSS009743|
African Ancestry|
6,017 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Eosinophil count — — Incremental R2 (full model vs. covariates alone): 0.0012 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013819 PSS009744|
East Asian Ancestry|
880 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Eosinophil count — — Incremental R2 (full model vs. covariates alone): 0.0108 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013868 PSS009745|
European Ancestry|
41,583 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Eosinophil count — — Incremental R2 (full model vs. covariates alone): 0.053 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM013917 PSS009746|
South Asian Ancestry|
7,446 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Eosinophil count — — Incremental R2 (full model vs. covariates alone): 0.0191 age, sex, age*sex, assessment center, genotyping array, 10 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009743 — — 6,017 individuals — African unspecified — UKB —
PSS009744 — — 880 individuals — East Asian — UKB —
PSS009745 — — 41,583 individuals — European Non-British European UKB —
PSS009746 — — 7,446 individuals — South Asian — UKB —