PGS Catalog - PGS002567 / Smoking status (Polygenic Score)

Polygenic Score (PGS) ID: PGS002567

Predicted Trait
Reported Trait	Smoking status
Mapped Trait(s)	smoking status measurement (EFO_0006527)

Released in PGS Catalog: June 9, 2022

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Score Details

Score Construction
PGS Name	cov_SMOKING_STATUS.P+T.1e-06
Development Method
Name	Pruning and Thresholding (P+T)
Parameters	p < 1e-06
Variants
Original Genome Build	GRCh37
Number of Variants	517
Effect Weight Type	beta

PGS Source
PGS Catalog Publication (PGP) ID	PGP000332
Citation (link to publication)	Weissbrod O et al. Nat Genet (2022)

Ancestry Distribution
Source of Variant Associations (GWAS)	European: 100% 336,312 individuals (100%)
PGS Evaluation	African: 25% East Asian: 25% European: 25% South Asian: 25% 4 Sample Sets

Development Samples

Source of Variant Associations (GWAS)

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Study Identifiers	Sample Numbers	Sample Ancestry	Cohort(s)
—	336,312 individuals	European	UKB

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Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

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PGS Performance Metric ID (PPM)	PGS Sample Set ID (PSS)	Performance Source	Trait	PGS Effect Sizes (per SD change)	Classification Metrics	Other Metrics	Covariates Included in the Model	PGS Performance: Other Relevant Information
PPM013989	PSS009835\| African Ancestry\| 6,455 individuals	PGP000332 \| Weissbrod O et al. Nat Genet (2022)	Reported Trait: Smoking status	—	—	Incremental R2 (full model vs. covariates alone): 0.0	age, sex, age*sex, assessment center, genotyping array, 10 PCs	—
PPM014038	PSS009836\| East Asian Ancestry\| 920 individuals	PGP000332 \| Weissbrod O et al. Nat Genet (2022)	Reported Trait: Smoking status	—	—	Incremental R2 (full model vs. covariates alone): 0.009	age, sex, age*sex, assessment center, genotyping array, 10 PCs	—
PPM014087	PSS009837\| European Ancestry\| 43,338 individuals	PGP000332 \| Weissbrod O et al. Nat Genet (2022)	Reported Trait: Smoking status	—	—	Incremental R2 (full model vs. covariates alone): 0.0047	age, sex, age*sex, assessment center, genotyping array, 10 PCs	—
PPM014136	PSS009838\| South Asian Ancestry\| 8,007 individuals	PGP000332 \| Weissbrod O et al. Nat Genet (2022)	Reported Trait: Smoking status	—	—	Incremental R2 (full model vs. covariates alone): 0.0029	age, sex, age*sex, assessment center, genotyping array, 10 PCs	—

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Evaluated Samples

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PGS Sample Set ID (PSS)	Phenotype Definitions and Methods	Participant Follow-up Time	Sample Numbers	Age of Study Participants	Sample Ancestry	Additional Ancestry Description	Cohort(s)	Additional Sample/Cohort Information
PSS009835	—	—	6,455 individuals	—	African unspecified	—	UKB	—
PSS009836	—	—	920 individuals	—	East Asian	—	UKB	—
PSS009837	—	—	43,338 individuals	—	European	Non-British European	UKB	—
PSS009838	—	—	8,007 individuals	—	South Asian	—	UKB	—

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