Polygenic Score (PGS) ID: PGS002598

Predicted Trait
Reported Trait Hair color
Mapped Trait(s) hair colour measurement (EFO_0007822)
Released in PGS Catalog: June 9, 2022
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Score Details

Score Construction
PGS Name pigment_HAIR.P+T.5e-08
Development Method
Name Pruning and Thresholding (P+T)
Parameters p < 5e-08
Variants
Original Genome Build GRCh37
Number of Variants 8,312
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000332
Citation (link to publication) Weissbrod O et al. Nat Genet (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
332,641 individuals (100%)
PGS Evaluation
African: 25%
East Asian: 25%
European: 25%
South Asian: 25%
4 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
— 332,641 individuals European UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM014167 PSS009763|
African Ancestry|
6,421 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Hair Color — — Incremental R2 (full model vs. covariates alone): 0.0074 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014216 PSS009764|
East Asian Ancestry|
916 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Hair Color — — Incremental R2 (full model vs. covariates alone): 0.0 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014265 PSS009765|
European Ancestry|
42,940 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Hair Color — — Incremental R2 (full model vs. covariates alone): 0.1815 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014314 PSS009766|
South Asian Ancestry|
7,961 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Hair Color — — Incremental R2 (full model vs. covariates alone): 0.0135 age, sex, age*sex, assessment center, genotyping array, 10 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009764 — — 916 individuals — East Asian — UKB —
PSS009765 — — 42,940 individuals — European Non-British European UKB —
PSS009766 — — 7,961 individuals — South Asian — UKB —
PSS009763 — — 6,421 individuals — African unspecified — UKB —