Polygenic Score (PGS) ID: PGS002621

Predicted Trait
Reported Trait Triglycerides
Mapped Trait(s) triglyceride measurement (EFO_0004530)
Released in PGS Catalog: June 9, 2022
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Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name biochemistry_Triglycerides.P+T.5e-08
Development Method
Name Pruning and Thresholding (P+T)
Parameters p < 5e-08
Variants
Original Genome Build GRCh37
Number of Variants 2,757
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000332
Citation (link to publication) Weissbrod O et al. Nat Genet (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
319,244 individuals (100%)
PGS Evaluation
African: 25%
East Asian: 25%
European: 25%
South Asian: 25%
4 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
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Study Identifiers
Sample Numbers
Sample Ancestry
Cohort(s)
319,244 individualsEuropeanUKB
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Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

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PGS Performance
Metric ID (PPM)
PGS Sample Set ID
(PSS)
Performance Source
Trait
PGS Effect Sizes
(per SD change)
Classification Metrics
Other Metrics
Covariates Included in the Model
PGS Performance:
Other Relevant Information
PPM014190PSS009855|
African Ancestry|
6,066 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: TriglyceridesIncremental R2 (full model vs. covariates alone): 0.0125age, sex, age*sex, assessment center, genotyping array, 10 PCs
PPM014239PSS009856|
East Asian Ancestry|
868 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: TriglyceridesIncremental R2 (full model vs. covariates alone): 0.0389age, sex, age*sex, assessment center, genotyping array, 10 PCs
PPM014288PSS009857|
European Ancestry|
40,890 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: TriglyceridesIncremental R2 (full model vs. covariates alone): 0.0522age, sex, age*sex, assessment center, genotyping array, 10 PCs
PPM014337PSS009858|
South Asian Ancestry|
7,553 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: TriglyceridesIncremental R2 (full model vs. covariates alone): 0.0579age, sex, age*sex, assessment center, genotyping array, 10 PCs
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Evaluated Samples

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PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods
Participant Follow-up Time
Sample Numbers
Age of Study Participants
Sample Ancestry
Additional Ancestry Description
Cohort(s)
Additional Sample/Cohort Information
PSS0098556,066 individualsAfrican unspecifiedUKB
PSS009856868 individualsEast AsianUKB
PSS00985740,890 individualsEuropeanNon-British EuropeanUKB
PSS0098587,553 individualsSouth AsianUKB
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