Polygenic Score (PGS) ID: PGS002636

Predicted Trait
Reported Trait College education
Mapped Trait(s) educational attainment (EFO_0011015)
Released in PGS Catalog: June 9, 2022
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Score Details

Score Construction
PGS Name cov_EDU_COLLEGE.PolyFun-pred
Development Method
Name PolyFun-pred
Parameters NR
Variants
Original Genome Build GRCh37
Number of Variants 577,448
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000332
Citation (link to publication) Weissbrod O et al. Nat Genet (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
334,353 individuals (100%)
PGS Evaluation
African: 25%
East Asian: 25%
European: 25%
South Asian: 25%
4 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
— 334,353 individuals European UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM014352 PSS009719|
African Ancestry|
6,277 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: College education — — Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.0023 age, sex, age*sex, assessment center, genotyping array, 10 PCs See cov_EDU_COLLEGE.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights
PPM014401 PSS009720|
East Asian Ancestry|
876 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: College education — — Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.0003 age, sex, age*sex, assessment center, genotyping array, 10 PCs See cov_EDU_COLLEGE.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights
PPM014450 PSS009721|
European Ancestry|
42,914 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: College education — — Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.0548 age, sex, age*sex, assessment center, genotyping array, 10 PCs See cov_EDU_COLLEGE.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights
PPM014499 PSS009722|
South Asian Ancestry|
7,658 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: College education — — Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.0224 age, sex, age*sex, assessment center, genotyping array, 10 PCs See cov_EDU_COLLEGE.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009719 — — 6,277 individuals — African unspecified — UKB —
PSS009720 — — 876 individuals — East Asian — UKB —
PSS009721 — — 42,914 individuals — European Non-British European UKB —
PSS009722 — — 7,658 individuals — South Asian — UKB —