Polygenic Score (PGS) ID: PGS002649

Predicted Trait
Reported Trait Height
Mapped Trait(s) body height (EFO_0004339)
Released in PGS Catalog: June 9, 2022
Download Score FTP directory
Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name body_HEIGHTz.PolyFun-pred
Development Method
Name PolyFun-pred
Parameters NR
Variants
Original Genome Build GRCh37
Number of Variants 478,839
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000332
Citation (link to publication) Weissbrod O et al. Nat Genet (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
336,759 individuals (100%)
PGS Evaluation
African: 25%
East Asian: 25%
European: 25%
South Asian: 25%
4 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
— 336,759 individuals European UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM014463 PSS009773|
European Ancestry|
43,376 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Height — — Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.3823 age, sex, age*sex, assessment center, genotyping array, 10 PCs See body_HEIGHTz.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights
PPM014365 PSS009771|
African Ancestry|
6,410 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Height — — Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.1149 age, sex, age*sex, assessment center, genotyping array, 10 PCs See body_HEIGHTz.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights
PPM014414 PSS009772|
East Asian Ancestry|
916 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Height — — Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.1634 age, sex, age*sex, assessment center, genotyping array, 10 PCs See body_HEIGHTz.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights
PPM014512 PSS009774|
South Asian Ancestry|
7,921 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Height — — Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.2378 age, sex, age*sex, assessment center, genotyping array, 10 PCs See body_HEIGHTz.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009772 — — 916 individuals — East Asian — UKB —
PSS009773 — — 43,376 individuals — European Non-British European UKB —
PSS009774 — — 7,921 individuals — South Asian — UKB —
PSS009771 — — 6,410 individuals — African unspecified — UKB —