Polygenic Score (PGS) ID: PGS002652

Predicted Trait
Reported Trait Hypertension
Mapped Trait(s) hypertension (EFO_0000537)
Released in PGS Catalog: June 9, 2022
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Score Details

Score Construction
PGS Name disease_HYPERTENSION_DIAGNOSED.PolyFun-pred
Development Method
Name PolyFun-pred
Parameters NR
Variants
Original Genome Build GRCh37
Number of Variants 385,766
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000332
Citation (link to publication) Weissbrod O et al. Nat Genet (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
336,972 individuals (100%)
PGS Evaluation
African: 25%
East Asian: 25%
European: 25%
South Asian: 25%
4 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
— 336,972 individuals European UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM014368 PSS009783|
African Ancestry|
6,438 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Hypertension — — Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.0195 age, sex, age*sex, assessment center, genotyping array, 10 PCs See disease_HYPERTENSION_DIAGNOSED.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights
PPM014417 PSS009784|
East Asian Ancestry|
913 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Hypertension — — Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.0417 age, sex, age*sex, assessment center, genotyping array, 10 PCs See disease_HYPERTENSION_DIAGNOSED.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights
PPM014466 PSS009785|
European Ancestry|
43,392 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Hypertension — — Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.0539 age, sex, age*sex, assessment center, genotyping array, 10 PCs See disease_HYPERTENSION_DIAGNOSED.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights
PPM014515 PSS009786|
South Asian Ancestry|
7,948 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Hypertension — — Incremental R2 (full model when combined with BOLT-LMM vs. covariates alone): 0.0476 age, sex, age*sex, assessment center, genotyping array, 10 PCs See disease_HYPERTENSION_DIAGNOSED.mixweights file at http://data.broadinstitute.org/alkesgroup/polypred_results for combination weights

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009783 — — 6,438 individuals — African unspecified — UKB —
PSS009784 — — 913 individuals — East Asian — UKB —
PSS009785 — — 43,392 individuals — European Non-British European UKB —
PSS009786 — — 7,948 individuals — South Asian — UKB —