Polygenic Score (PGS) ID: PGS002679

Predicted Trait
Reported Trait Body mass index (BMI)
Mapped Trait(s) body mass index (EFO_0004340)
Released in PGS Catalog: June 9, 2022
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Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name body_BMIz.SBayesR
Development Method
Name SBayesR
Parameters NR
Variants
Original Genome Build GRCh37
Number of Variants 987,879
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000332
Citation (link to publication) Weissbrod O et al. Nat Genet (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
336,394 individuals (100%)
PGS Evaluation
African: 25%
East Asian: 25%
European: 25%
South Asian: 25%
4 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
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Study Identifiers
Sample Numbers
Sample Ancestry
Cohort(s)
336,394 individualsEuropeanUKB
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Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

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PGS Performance
Metric ID (PPM)
PGS Sample Set ID
(PSS)
Performance Source
Trait
PGS Effect Sizes
(per SD change)
Classification Metrics
Other Metrics
Covariates Included in the Model
PGS Performance:
Other Relevant Information
PPM014542PSS009695|
African Ancestry|
6,399 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: BMIIncremental R2 (full model vs. covariates alone): 0.0317age, sex, age*sex, assessment center, genotyping array, 10 PCs
PPM014591PSS009696|
East Asian Ancestry|
916 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: BMIIncremental R2 (full model vs. covariates alone): 0.0587age, sex, age*sex, assessment center, genotyping array, 10 PCs
PPM014640PSS009697|
European Ancestry|
43,328 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: BMIIncremental R2 (full model vs. covariates alone): 0.1271age, sex, age*sex, assessment center, genotyping array, 10 PCs
PPM014689PSS009698|
South Asian Ancestry|
7,911 individuals
PGP000332 |
Weissbrod O et al. Nat Genet (2022)
Reported Trait: BMIIncremental R2 (full model vs. covariates alone): 0.0823age, sex, age*sex, assessment center, genotyping array, 10 PCs
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Evaluated Samples

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PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods
Participant Follow-up Time
Sample Numbers
Age of Study Participants
Sample Ancestry
Additional Ancestry Description
Cohort(s)
Additional Sample/Cohort Information
PSS0096956,399 individualsAfrican unspecifiedUKB
PSS009696916 individualsEast AsianUKB
PSS00969743,328 individualsEuropeanNon-British EuropeanUKB
PSS0096987,911 individualsSouth AsianUKB
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