Polygenic Score (PGS) ID: PGS002683

Predicted Trait
Reported Trait Childless
Mapped Trait(s) reproductive behaviour measurement (EFO_0007862)
Released in PGS Catalog: June 9, 2022
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Score Details

Score Construction
PGS Name repro_ChildLess.SBayesR
Development Method
Name SBayesR
Parameters NR
Variants
Original Genome Build GRCh37
Number of Variants 954,898
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000332
Citation (link to publication) Weissbrod O et al. Nat Genet (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
335,600 individuals (100%)
PGS Evaluation
African: 25%
East Asian: 25%
European: 25%
South Asian: 25%
4 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
— 335,600 individuals European UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM014546 PSS009711|
African Ancestry|
6,193 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Childless — — Incremental R2 (full model vs. covariates alone): 0.0023 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014595 PSS009712|
East Asian Ancestry|
909 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Childless — — Incremental R2 (full model vs. covariates alone): 0.0043 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014644 PSS009713|
European Ancestry|
43,069 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Childless — — Incremental R2 (full model vs. covariates alone): 0.0053 age, sex, age*sex, assessment center, genotyping array, 10 PCs —
PPM014693 PSS009714|
South Asian Ancestry|
7,846 individuals
 PGP000332 |
Weissbrod O et al. Nat Genet (2022)
 Reported Trait: Childless — — Incremental R2 (full model vs. covariates alone): 0.0016 age, sex, age*sex, assessment center, genotyping array, 10 PCs —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009711 — — 6,193 individuals — African unspecified — UKB —
PSS009712 — — 909 individuals — East Asian — UKB —
PSS009713 — — 43,069 individuals — European Non-British European UKB —
PSS009714 — — 7,846 individuals — South Asian — UKB —