Polygenic Score (PGS) ID: PGS002735

Predicted Trait
Reported Trait Endometrial cancer
Mapped Trait(s) endometrial carcinoma (EFO_1001512)
Released in PGS Catalog: July 21, 2022
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Score Details

Score Construction
PGS Name PRS19
Development Method
Name Genome-wide significant variants
Parameters p<1E-05, r2<0.2
Variants
Original Genome Build NR
Number of Variants 19
Effect Weight Type log(OR)
PGS Source
PGS Catalog Publication (PGP) ID PGP000344
Citation (link to publication) Bafligil C et al. Genet Med (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
Not Reported: 100%
Score Development/Training
European: 100%
1,757 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
Europe PMC: 32066633
 NR Not reported NR
Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
—
[
  • 555 cases
  • , 1,202 controls
]
,
0.0 % Male samples
 European NR — — — — Manchester study

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM014832 PSS009907|
European Ancestry|
118,636 individuals
 PGP000344 |
Bafligil C et al. Genet Med (2022)
 Reported Trait: Risk of endometrial cancer — AUROC: 0.56 [0.54, 0.57] Odds ratio (OR, third vs first tertile): 1.55 [1.37, 1.74] — —
PPM014835 PSS009907|
European Ancestry|
118,636 individuals
 PGP000344 |
Bafligil C et al. Genet Med (2022)
 Reported Trait: Risk of endometrial cancer HR: 0.2 [0.15, 0.25] — — BMI —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009907 — —
[
  • 1,676 cases
  • , 116,960 controls
]
,
0.0 % Male samples
 — European — NR UKB