Polygenic Score (PGS) ID: PGS002778

Predicted Trait
Reported Trait Incident hypertension
Mapped Trait(s) hypertension (EFO_0000537)
Released in PGS Catalog: Dec. 20, 2022
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Terms and Licenses
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)

Score Details

Score Construction
PGS Name GTG_Hypertension_SCT
Development Method
Name Stacked clumping and thresholding (SCT)
Parameters SCT(bigsnpr) using default hyperparameters
Variants
Original Genome Build hg19
Number of Variants 309,759
Effect Weight Type NR
PGS Source
PGS Catalog Publication (PGP) ID PGP000365
Citation (link to publication) Wong CK et al. PLoS One (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
458,554 individuals (100%)
Score Development/Training
European: 100%
51,273 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST007610
Europe PMC: 30940143
 458,554 individuals European CARDIoGRAMplusC4D, UKB
Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
—
[
  • 10,255 cases
  • , 41,018 controls
]
,
52.0 % Male samples
 European UKB We used the disease definitions described in the supplement of Said et al (2018). PMID: 29955826 — — —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM014978 PSS009942|
European Ancestry|
21,970 individuals
 PGP000365 |
Wong CK et al. PLoS One (2022)
 Reported Trait: Incident hypertension OR: 1.26 [1.22, 1.3] AUROC: 0.566 [0.556, 0.576] — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009942 We used the disease definitions described in the supplement of Said et al (2018). PMID: 29955826 —
[
  • 4,394 cases
  • , 17,576 controls
]
,
42.0 % Male samples
 European — UKB —