Polygenic Score (PGS) ID: PGS002812

Predicted Trait
Reported Trait Gluteofemoral adipose tissue volumes adjusted for BMI and height
Mapped Trait(s) adipose amount (OBA_VT0005452)
Released in PGS Catalog: Nov. 7, 2022
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PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name GFATadjbmi3_weights_select
Development Method
Name LDpred2
Parameters HapMap3 variants with MAF > 0.5%; LD reference = 350,000 White British ancestry individuals
Variants
Original Genome Build GRCh37
Number of Variants 1,125,301
Effect Weight Type NR
PGS Source
PGS Catalog Publication (PGP) ID PGP000391
Citation (link to publication) Agrawal S et al. Nat Commun (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
Multi-ancestry (including European): 100%
  • European
  • African
  • East Asian
  • South Asian
  • Not Reported
37,641 individuals (100%)
PGS Evaluation
Multi-ancestry (including European): 66.7%
  • European
  • African
  • East Asian
  • South Asian
  • Not Reported
European: 33.3%
3 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
— 37,641 individuals European, African unspecified, East Asian, South Asian, Not reported UKB

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM015588 PSS009993|
Multi-ancestry (including European)|
7,795 individuals
 PGP000391 |
Agrawal S et al. Nat Commun (2022)
 Reported Trait: Gluteofemoral adipose tissue volumes adjusted for BMI and height β: 0.262 (0.016) — Odds ratio (OR, top 5% vs reminder): 3.81 [2.76, 5.17] Age at time of imaging, sex, and the first 10 PCs of genetic ancestry —
PPM015590 PSS009992|
European Ancestry|
7,888 individuals
 PGP000391 |
Agrawal S et al. Nat Commun (2022)
 Reported Trait: HDL cholesterol — — Beta (top 10 % vs reminder): 0.14 [0.07, 0.22] Age at enrollment, sex, and the first 10 principal components of genetic ancestry —
PPM015591 PSS009992|
European Ancestry|
7,888 individuals
 PGP000391 |
Agrawal S et al. Nat Commun (2022)
 Reported Trait: Triglycerides — — Beta (top 10 % vs reminder): -0.16 [-0.23, -0.08] Age at enrollment, sex, and the first 10 principal components of genetic ancestry —
PPM015593 PSS009992|
European Ancestry|
7,888 individuals
 PGP000391 |
Agrawal S et al. Nat Commun (2022)
 Reported Trait: Type 2 Diabetes — — Odds ratio (OR, top 10% vs reminder): 0.57 [0.41, 0.78] Age at enrollment, sex, and the first 10 principal components of genetic ancestry —
PPM015594 PSS009994|
Multi-ancestry (including European)|
447,486 individuals
 PGP000391 |
Agrawal S et al. Nat Commun (2022)
 Reported Trait: HDL cholesterol — — Beta (top 10 % vs reminder): 0.16 [0.15, 0.18] — —
PPM015595 PSS009994|
Multi-ancestry (including European)|
447,486 individuals
 PGP000391 |
Agrawal S et al. Nat Commun (2022)
 Reported Trait: Triglycerides — — Beta (top 10 % vs reminder): -0.16 [-0.18, -0.15] — —
PPM015596 PSS009994|
Multi-ancestry (including European)|
447,486 individuals
 PGP000391 |
Agrawal S et al. Nat Commun (2022)
 Reported Trait: Alanine aminotransferase — — Beta (top 10 % vs reminder): -0.09 [-0.1, -0.07] — —
PPM015597 PSS009994|
Multi-ancestry (including European)|
447,486 individuals
 PGP000391 |
Agrawal S et al. Nat Commun (2022)
 Reported Trait: Type 2 Diabetes — — Odds ratio (OR, top 10% vs reminder): 0.75 [0.7, 0.8] — —
PPM015598 PSS009994|
Multi-ancestry (including European)|
447,486 individuals
 PGP000391 |
Agrawal S et al. Nat Commun (2022)
 Reported Trait: Coronary artery disease — — Odds ratio (OR, top 10% vs reminder): 0.89 [0.85, 0.93] — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS009992 — — 7,888 individuals — European
(White)		 — ARIC —
PSS009993 — — 7,795 individuals — European, African unspecified, East Asian, South Asian, Not reported White British, Black, East Asian, South Asian, Other UKB 20% of original GWAS cohort
PSS009994 — — 447,486 individuals — European, African unspecified, East Asian, South Asian, Not reported White British, Black, East Asian, South Asian, Other UKB Unimaged cohort of UKB