PGS Catalog - PGS002812 / Gluteofemoral adipose tissue volumes adjusted for BMI and height (Polygenic Score)

Polygenic Score (PGS) ID: PGS002812

Predicted Trait
Reported Trait	Gluteofemoral adipose tissue volumes adjusted for BMI and height
Mapped Trait(s)	adipose amount (OBA_VT0005452)

Released in PGS Catalog: Nov. 7, 2022

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Score Details

Score Construction
PGS Name	GFATadjbmi3_weights_select
Development Method
Name	LDpred2
Parameters	HapMap3 variants with MAF > 0.5%; LD reference = 350,000 White British ancestry individuals
Variants
Original Genome Build	GRCh37
Number of Variants	1,125,301
Effect Weight Type	NR

PGS Source
PGS Catalog Publication (PGP) ID	PGP000391
Citation (link to publication)	Agrawal S et al. Nat Commun (2022)

Ancestry Distribution
Source of Variant Associations (GWAS)	Multi-ancestry (including European): 100% European African East Asian South Asian Not Reported 37,641 individuals (100%)
PGS Evaluation	Multi-ancestry (including European): 66.7% European African East Asian South Asian Not Reported European: 33.3% 3 Sample Sets

Development Samples

Source of Variant Associations (GWAS)

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Study Identifiers	Sample Numbers	Sample Ancestry	Cohort(s)
—	37,641 individuals	European, African unspecified, East Asian, South Asian, Not reported	UKB

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Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

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PGS Performance Metric ID (PPM)	PGS Sample Set ID (PSS)	Performance Source	Trait	PGS Effect Sizes (per SD change)	Classification Metrics	Other Metrics	Covariates Included in the Model	PGS Performance: Other Relevant Information
PPM015588	PSS009993\| Multi-ancestry (including European)\| 7,795 individuals	PGP000391 \| Agrawal S et al. Nat Commun (2022)	Reported Trait: Gluteofemoral adipose tissue volumes adjusted for BMI and height	β: 0.262 (0.016)	—	Odds ratio (OR, top 5% vs reminder): 3.81 [2.76, 5.17]	Age at time of imaging, sex, and the first 10 PCs of genetic ancestry	—
PPM015590	PSS009992\| European Ancestry\| 7,888 individuals	PGP000391 \| Agrawal S et al. Nat Commun (2022)	Reported Trait: HDL cholesterol	—	—	Beta (top 10 % vs reminder): 0.14 [0.07, 0.22]	Age at enrollment, sex, and the first 10 principal components of genetic ancestry	—
PPM015591	PSS009992\| European Ancestry\| 7,888 individuals	PGP000391 \| Agrawal S et al. Nat Commun (2022)	Reported Trait: Triglycerides	—	—	Beta (top 10 % vs reminder): -0.16 [-0.23, -0.08]	Age at enrollment, sex, and the first 10 principal components of genetic ancestry	—
PPM015593	PSS009992\| European Ancestry\| 7,888 individuals	PGP000391 \| Agrawal S et al. Nat Commun (2022)	Reported Trait: Type 2 Diabetes	—	—	Odds ratio (OR, top 10% vs reminder): 0.57 [0.41, 0.78]	Age at enrollment, sex, and the first 10 principal components of genetic ancestry	—
PPM015594	PSS009994\| Multi-ancestry (including European)\| 447,486 individuals	PGP000391 \| Agrawal S et al. Nat Commun (2022)	Reported Trait: HDL cholesterol	—	—	Beta (top 10 % vs reminder): 0.16 [0.15, 0.18]	—	—
PPM015595	PSS009994\| Multi-ancestry (including European)\| 447,486 individuals	PGP000391 \| Agrawal S et al. Nat Commun (2022)	Reported Trait: Triglycerides	—	—	Beta (top 10 % vs reminder): -0.16 [-0.18, -0.15]	—	—
PPM015596	PSS009994\| Multi-ancestry (including European)\| 447,486 individuals	PGP000391 \| Agrawal S et al. Nat Commun (2022)	Reported Trait: Alanine aminotransferase	—	—	Beta (top 10 % vs reminder): -0.09 [-0.1, -0.07]	—	—
PPM015597	PSS009994\| Multi-ancestry (including European)\| 447,486 individuals	PGP000391 \| Agrawal S et al. Nat Commun (2022)	Reported Trait: Type 2 Diabetes	—	—	Odds ratio (OR, top 10% vs reminder): 0.75 [0.7, 0.8]	—	—
PPM015598	PSS009994\| Multi-ancestry (including European)\| 447,486 individuals	PGP000391 \| Agrawal S et al. Nat Commun (2022)	Reported Trait: Coronary artery disease	—	—	Odds ratio (OR, top 10% vs reminder): 0.89 [0.85, 0.93]	—	—

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Evaluated Samples

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PGS Sample Set ID (PSS)	Phenotype Definitions and Methods	Participant Follow-up Time	Sample Numbers	Age of Study Participants	Sample Ancestry	Additional Ancestry Description	Cohort(s)	Additional Sample/Cohort Information
PSS009992	—	—	7,888 individuals	—	European (White)	—	ARIC	—
PSS009993	—	—	7,795 individuals	—	European, African unspecified, East Asian, South Asian, Not reported	White British, Black, East Asian, South Asian, Other	UKB	20% of original GWAS cohort
PSS009994	—	—	447,486 individuals	—	European, African unspecified, East Asian, South Asian, Not reported	White British, Black, East Asian, South Asian, Other	UKB	Unimaged cohort of UKB

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