Polygenic Score (PGS) ID: PGS002812

Predicted Trait
Reported Trait Gluteofemoral adipose tissue volumes adjusted for BMI and height
Mapped Trait(s) adipose amount (OBA_VT0005452)
Released in PGS Catalog: Nov. 7, 2022
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Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name GFATadjbmi3_weights_select
Development Method
Name LDpred2
Parameters HapMap3 variants with MAF > 0.5%; LD reference = 350,000 White British ancestry individuals
Variants
Original Genome Build GRCh37
Number of Variants 1,125,301
Effect Weight Type NR
PGS Source
PGS Catalog Publication (PGP) ID PGP000391
Citation (link to publication) Agrawal S et al. Nat Commun (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
Multi-ancestry (including European): 100%
  • European
  • African
  • East Asian
  • South Asian
  • Not Reported
37,641 individuals (100%)
PGS Evaluation
Multi-ancestry (including European): 66.7%
  • European
  • African
  • East Asian
  • South Asian
  • Not Reported
European: 33.3%
3 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
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Study Identifiers
Sample Numbers
Sample Ancestry
Cohort(s)
37,641 individualsEuropean, African unspecified, East Asian, South Asian, Not reportedUKB
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Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

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PGS Performance
Metric ID (PPM)
PGS Sample Set ID
(PSS)
Performance Source
Trait
PGS Effect Sizes
(per SD change)
Classification Metrics
Other Metrics
Covariates Included in the Model
PGS Performance:
Other Relevant Information
PPM015588PSS009993|
Multi-ancestry (including European)|
7,795 individuals
PGP000391 |
Agrawal S et al. Nat Commun (2022)
Reported Trait: Gluteofemoral adipose tissue volumes adjusted for BMI and heightβ: 0.262 (0.016)Odds ratio (OR, top 5% vs reminder): 3.81 [2.76, 5.17]Age at time of imaging, sex, and the first 10 PCs of genetic ancestry
PPM015590PSS009992|
European Ancestry|
7,888 individuals
PGP000391 |
Agrawal S et al. Nat Commun (2022)
Reported Trait: HDL cholesterolBeta (top 10 % vs reminder): 0.14 [0.07, 0.22]Age at enrollment, sex, and the first 10 principal components of genetic ancestry
PPM015591PSS009992|
European Ancestry|
7,888 individuals
PGP000391 |
Agrawal S et al. Nat Commun (2022)
Reported Trait: TriglyceridesBeta (top 10 % vs reminder): -0.16 [-0.23, -0.08]Age at enrollment, sex, and the first 10 principal components of genetic ancestry
PPM015593PSS009992|
European Ancestry|
7,888 individuals
PGP000391 |
Agrawal S et al. Nat Commun (2022)
Reported Trait: Type 2 DiabetesOdds ratio (OR, top 10% vs reminder): 0.57 [0.41, 0.78]Age at enrollment, sex, and the first 10 principal components of genetic ancestry
PPM015594PSS009994|
Multi-ancestry (including European)|
447,486 individuals
PGP000391 |
Agrawal S et al. Nat Commun (2022)
Reported Trait: HDL cholesterolBeta (top 10 % vs reminder): 0.16 [0.15, 0.18]
PPM015595PSS009994|
Multi-ancestry (including European)|
447,486 individuals
PGP000391 |
Agrawal S et al. Nat Commun (2022)
Reported Trait: TriglyceridesBeta (top 10 % vs reminder): -0.16 [-0.18, -0.15]
PPM015596PSS009994|
Multi-ancestry (including European)|
447,486 individuals
PGP000391 |
Agrawal S et al. Nat Commun (2022)
Reported Trait: Alanine aminotransferaseBeta (top 10 % vs reminder): -0.09 [-0.1, -0.07]
PPM015597PSS009994|
Multi-ancestry (including European)|
447,486 individuals
PGP000391 |
Agrawal S et al. Nat Commun (2022)
Reported Trait: Type 2 DiabetesOdds ratio (OR, top 10% vs reminder): 0.75 [0.7, 0.8]
PPM015598PSS009994|
Multi-ancestry (including European)|
447,486 individuals
PGP000391 |
Agrawal S et al. Nat Commun (2022)
Reported Trait: Coronary artery diseaseOdds ratio (OR, top 10% vs reminder): 0.89 [0.85, 0.93]
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Evaluated Samples

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PGS Sample Set ID
(PSS)
Phenotype Definitions and Methods
Participant Follow-up Time
Sample Numbers
Age of Study Participants
Sample Ancestry
Additional Ancestry Description
Cohort(s)
Additional Sample/Cohort Information
PSS0099927,888 individualsEuropean
(White)
ARIC
PSS0099937,795 individualsEuropean, African unspecified, East Asian, South Asian, Not reportedWhite British, Black, East Asian, South Asian, OtherUKB20% of original GWAS cohort
PSS009994447,486 individualsEuropean, African unspecified, East Asian, South Asian, Not reportedWhite British, Black, East Asian, South Asian, OtherUKBUnimaged cohort of UKB
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