PGS Catalog - PGS003020 / Hypertension (Polygenic Score)

Polygenic Score (PGS) ID: PGS003020

Predicted Trait
Reported Trait	Hypertension
Mapped Trait(s)	hypertension (EFO_0000537)
Additional Trait Information	Diagnoses - main ICD10: I10 Essential (primary) hypertension; Binary

Released in PGS Catalog: Nov. 23, 2022

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Terms and Licenses

PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name	ExPRSweb_Hypertension_finngen-R4-FG_PT_UKB_20211120
Development Method
Name	Pruning and Thresholding (P+T)
Parameters	LD Clumping (using Plink to calculate LD, MAF >= 1%, r^2 <= 0.1) & P-value threshold <=... 3.98e^-06Show more
Variants
Original Genome Build	GRCh37
Number of Variants	24
Effect Weight Type	beta

PGS Source
PGS Catalog Publication (PGP) ID	PGP000393
Citation (link to publication)	Ma Y et al. Am J Hum Genet (2022)

Ancestry Distribution
Source of Variant Associations (GWAS)	European: 100% 166,552 individuals (100%)
Score Development/Training	European: 100% 203,607 individuals (100%)
PGS Evaluation	European: 100% 1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)

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Study Identifiers	Sample Numbers	Sample Ancestry	Cohort(s)
—	166,552 individuals [ 33,229 cases , 133,323 controls ]	European	FinnGen

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Score Development/Training

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Study Identifiers	Sample Numbers	Sample Ancestry	Cohort(s)	Phenotype Definitions & Methods	Age of Study Participants	Participant Follow-up Time	Additional Ancestry Description	Additional Sample/Cohort Information
—	203,607 individuals [ 38,849 cases , 164,758 controls ]	European	NR	PheCode 401.1 (http://phewascatalog.org/); Binary	—	—	—	—

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Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

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PGS Performance Metric ID (PPM)	PGS Sample Set ID (PSS)	Performance Source	Trait	PGS Effect Sizes (per SD change)	Classification Metrics	Other Metrics	Covariates Included in the Model	PGS Performance: Other Relevant Information
PPM015896	PSS010030\| European Ancestry\| 203,639 individuals	PGP000393 \| Ma Y et al. Am J Hum Genet (2022)	Reported Trait: Hypertension	OR: 0.992 [0.98, 1.003] β: -0.00832 (0.00587)	AUROC: 0.506 [0.503, 0.509]	—	Sex,birthYear,genotyping.array,PC1,PC2,PC3,PC4	—

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Evaluated Samples

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PGS Sample Set ID (PSS)	Phenotype Definitions and Methods	Participant Follow-up Time	Sample Numbers	Age of Study Participants	Sample Ancestry	Additional Ancestry Description	Cohort(s)	Additional Sample/Cohort Information
PSS010030	PheCode 401.1 (http://phewascatalog.org/); Binary	—	203,639 individuals [ 38,801 cases , 164,838 controls ]	—	European	—	UKB	—

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