Polygenic Score (PGS) ID: PGS003399

Predicted Trait
Reported Trait Breast cancer
Mapped Trait(s) breast carcinoma (EFO_0000305)
Released in PGS Catalog: Jan. 19, 2023
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Score Details

Score Construction
PGS Name PRS-209EUR
Development Method
Name Genome-wide significant SNPs
Parameters r2>0.8
Variants
Original Genome Build GRCh37
Number of Variants 209
Effect Weight Type beta
PGS Source
PGS Catalog Publication (PGP) ID PGP000415
Citation (link to publication) Jee YH et al. Int J Epidemiol (2022)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
169,092 individuals (100%)
PGS Evaluation
East Asian: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
Europe PMC: 30554720
[
  • 94,075 cases
  • , 75,017 controls
]
,
0.0 % Male samples
 European BCAC

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM016283 PSS010095|
East Asian Ancestry|
41,031 individuals
 PGP000415 |
Jee YH et al. Int J Epidemiol (2022)
 Reported Trait: Occurrence of breast cancer HR: 1.54 [1.43, 1.66] AUROC: 0.62 [0.6, 0.64] — principal component —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS010095 — — 41,031 individuals,
0.0 % Male samples
 — East Asian
(Korean)		 — KCPS KPCS-II