Polygenic Score (PGS) ID: PGS003409

Predicted Trait
Reported Trait Intracranial aneurysm
Mapped Trait(s) brain aneurysm (EFO_0003870)
Additional Trait Information Unruptured intracranial aneurysm + aneurysmal subarachnoid hemorrhage
Released in PGS Catalog: Jan. 24, 2023
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Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name 4_withUKB_sexAll_IAonly.weights
Development Method
Name elastic net (metaGRS)
Parameters For each trait the best performing among the following models: s-Bayes R, GCTA-BLUP, clumping (9 r-squared thresholds). Then, elastic net regression to obtain per-trait shrinking factors
Variants
Original Genome Build GRCh37
Number of Variants 6,852,195
Effect Weight Type metaGRS
PGS Source
PGS Catalog Publication (PGP) ID PGP000423
Citation (link to publication) Bakker MK et al. Stroke (2023)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
79,429 individuals (100%)
Score Development/Training
European: 100%
408,553 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
GWAS Catalog: GCST011020
[
  • 7,495 cases
  • , 71,934 controls
]
 European
(Dutch,Swiss,British,Australian,American,French,French Canadian,Finnish,Polish,Norwegian)		 8 cohorts
  • ARIC
  • ,BHS
  • ,GAIN
  • ,HUNT
  • ,NBS
  • ,NFBC
  • ,UKB
  • ,UMC
Score Development/Training
Study Identifiers Sample Numbers Sample Ancestry Cohort(s) Phenotype Definitions & Methods Age of Study Participants Participant Follow-up Time Additional Ancestry Description Additional Sample/Cohort Information
—
[
  • 1,161 cases
  • , 407,392 controls
]
 European
(British)		 UKB ICD codes I67.1 and I60 — — — —

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM017051 PSS010105|
European Ancestry|
69,396 individuals
 PGP000423 |
Bakker MK et al. Stroke (2023)
 Reported Trait: Aneurysmal subarachnoid hemorrhage hazard HR: 1.254 C-index: 0.65 — sex, systolic blood pressure, cigarette packs per day —
PPM017057 PSS010105|
European Ancestry|
69,396 individuals
 PGP000423 |
Bakker MK et al. Stroke (2023)
 Reported Trait: Intracranial aneurysm cases OR: 1.124 C-index: 0.764 — — —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS010105 ICD codes I67.1 and I60 —
[
  • 828 cases
  • , 68,568 controls
]
 — European
(Norwegian)		 — HUNT2 —