Predicted Trait | |
Reported Trait | Abdominal aortic aneurysm |
Mapped Trait(s) | Abdominal Aortic Aneurysm (EFO_0004214) |
Score Construction | |
PGS Name | AAA |
Development Method | |
Name | shaPRS + LDpred2 |
Parameters | auto option (for both shaPRS and LDpred2) |
Variants | |
Original Genome Build | GRCh37 |
Number of Variants | 831,447 |
Effect Weight Type | beta |
PGS Source | |
PGS Catalog Publication (PGP) ID | PGP000436 |
Citation (link to publication) | Kelemen M et al. Nat Commun (2024) |
Ancestry Distribution | |
Source of Variant Associations (GWAS) | |
PGS Evaluation | European: 100% 1 Sample Sets |
Study Identifiers | Sample Numbers | Sample Ancestry | Cohort(s) |
---|---|---|---|
Europe PMC: 25826379 |
[
|
European (U.K.) |
UKB |
Europe PMC: 25826379 |
[
|
European (U.K.) |
UKB |
— | 104,179 individuals | European | NR |
GWAS Catalog: GCST004787 Europe PMC: 28714975 |
[
|
European, NR | NR |
PGS Performance Metric ID (PPM) |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
---|---|---|---|---|---|---|---|---|
PPM017103 | PSS010126| European Ancestry| 91,731 individuals |
PGP000436 | Kelemen M et al. Nat Commun (2024) |
Reported Trait: Abdominal aortic aneurysm | — | AUROC: 0.708 [0.691, 0.725] | R²: 0.00547 | — | — |
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
---|---|---|---|---|---|---|---|---|
PSS010126 | — | — | [
|
— | European (U.K.) |
— | UKB | — |